The thermogenesis of the early development of African clawed frog, Xenopus laevis, was measured by isothermal calorimetry. The time variation of the thermogenesis was interpreted on the basis of an crystal growth model with Avrami index n = 3/2. The temperature variation experiment revealed that the crystal growth rates τc-1 were in proportion to the frequencies of cell cycles τ0-1 of the activated oocytes.