Yukari Fujimoto

Yukari FUJIMOTO, Ph.D.

Associate Professor
Laboratory for Natural Products Chemistry
Department of Chemistry, Graduate School of Science
Osaka University

Address: 1-1 Machikaneyama, Toyonaka, 560-0043, Osaka, Japan
E-mail: yukarif @ chem.sci.osaka-u.ac.jp

　-> Osaka University Faculty/Researchers Search
　　　Osaka University Global COE Program, Frontier Biomedical Science Underlying Organelle Network Biology
　　　The Funding Program for Next Generation World-Leading Researchers / Osaka University

 

｜Professional History｜
　1989　　　Sumitomo Chemical Co. Ltd. / Research Scientist
　1998　　　Columbia University / Research Associate
　2002　　　Nagoya University / Postdoctoral Fellow
　2003　　　Department of Chemistry, Graduate School of Science, Osaka University / Assistant Professor
　2006　　　Department of Chemistry, Graduate School of Science, Osaka University / Associate Professor (Koushi)

　2008~present　　Department of Chemistry, Graduate School of Science, Osaka University / Associate Professor

｜Awards｜
　2012　　　The Alois Nowotny Award (International Endotoxin & Innate Immunity Society)
　2008　　　BCSJ (Bulletin of the Chemical Society of Japan) Award (The Chemical Society of Japan)
　2008　　　Osaka University Achievement Award (Osaka University)
　2007　　　25th Incentive Award in Synthetic Organic Chemistry, Japan (The Society of Synthetic Organic Chemistry, Japan)

｜Research Keywords｜
　Bioorganic Chemistry, Glycoconjugates, Innate Immunity, Immune adjuvants

｜Profile｜Major research areas are Bioorganic chemistry, Glycochemistry, Natural compoun dchemistry. Current research focuses on the Immunoregulatory microbial compounds, including chemical synthesis, functional analysis, and producing new regulatory-molecule complex.

｜Representative publication｜ 　The list of all publications→ Here

 
  1. Fujimoto, Y., Pradipta, A. R., Inohara, N., Fukase, K., Peptidoglycan as Nod1 ligand; Fragment structures in the environment, chemical synthesis, and their innate immunostimulation. Nat. Prod. Rep. 2012, 29, 568-579.
  2. Shimoyama, A., Saeki, A., Tanimura, N., Tsutsui, H., Miyake, K., Suda, Y., Fujimoto, Y., Fukase. K., Chemical synthesis of Helicobacter pylori lipopolysaccharide partial structures and their selective proinflammatory response. Chem. Eur. J. 2011, 17, 14464-14474.
  3. Pradipta, A. R., Fujimoto, Y., Hasegawa, M., Inohara, N., Fukase, K. Characterization of natural human nucleotide-binding oligomerization domain protein 1 (NOD1) ligands from bacterial culture supernatant for elucidation of immune modulators in the environment. J. Biol. Chem. 2010, 285, 23607-23613.
  4. Fujimoto, Y., Hashimoto, M., Furuyashiki, M., Katsumoto, M., Seya, T., Suda, Y., Fukase, K.  Lipopeptides from Staphylococcus aureus as Tlr2 Ligands: Prediction with mRNA Expression, Chemical Synthesis, and Immunostimulatory Activities. ChemBioChem, 2009, 10(14), 2311-2315.
  5. Kawasaki, A., Karasudani, Y., Otsuka, Y., Hasegawa, M., Inohara, N., Fujimoto, Y., Fukase, K. Synthesis of diaminopimelic acid-containing peptidoglycan fragments and tracheal cytotoxin (TCT) for investigation of their biological functions. Chem. Eur. J. 2008, 14, 10318-10330.
  6. Fujimoto, Y., Inamura, S., Kawasaki, A., Shiokawa, Z., Shimoyama, A., Hashimoto, T., Kusumoto, S., Fukase, K., Chemical synthesis of peptidoglycan fragments for elucidation of the immunostimulating mechanism. J. Endotoxin Research 2007, 13, 189-196.
  7. Fujimoto, Y., Synthesis and functional analysis of the key compounds responsible for signal transduction. J. Synth. Org. Chem. Jpn. 2007, 65, 1170-1178.
  8. Inamura, S., Fujimoto, Y., Kawasaki, A., Shiokawa, Z., Woelk, E., Heine, H., Lindner, B., Inohara, N., Kusumoto, S., Fukase, K., Synthesis of peptidoglycan fragments and evaluation of their biological activity. Org. Biomol. Chem. 2006, 4, 232-242.
  9. Hirota, S., Fujimoto, Y., Choi, J., Baden, N., Katagiri, N., Akiyama, M., Hulsker, R., Ubbink, M., Okajima, T., Takabe, T., Funasaki, N., Watanabe, Y., Terazima, M., Conformational Changes during Apoplastocyanin Folding Observed by Photocleavable Modification and Transient Grating. J. Am. Chem. Soc. 2006, 128, 7551-7558.
  10. Fujimoto, Y., Fishkin, N., Pescitelli, G., Decatur, J., Berova, N., Nakanishi, K., Solution and Biologically Relevant Conformations of Enantiomeric 11-cis-Locked Cyclopropyl Retinals. J. Am. Chem. Soc. 2002, 124, 7294-7302.

｜Books｜ 　

 
  1. Fujimoto, Y., Tanaka, K., Shimoyama, A., Fukase, K. Methods in Enzymology; Self and non-self recognition with bacterial and animal glycans, surveys by synthetic chemistry. Minoru Fukuda Ed. Elsevier, 2010, volume 478, pp.323-342.
  2. Fukase, K., Fujimoto, Y. Synthesis and biofunctional studies of bacterial immunostimulating glycoconjugates. In Progress in the synthesis of complex carbohydrate chains of plant and microbial polysaccharides. Nikolay E. Nifantiev Ed. Research Signpost and Transworld Research Network, 2009; pp.279-308.
  3. Kusumoto, S., Fukase, K., Fujimoto, Y. Chemical synthesis of bacterial lipid A. In Microbial Glycobiology: Structures, Relevance and Applications, Anthon Moran, Otto Holst, Patrick J Brennan, Mark von Itzstein Eds. Elsevier: London, 2009; pp.415-427.
  4. Fukase, K., Fujimoto, Y., Tanaka, K. Chemical Synthesis of Sugar Chains In Experimental Glycoscience, “Glycochemistry”, Taniguchi, N., Suzuki, A., Ito, Y., Narimatsu, H., Kawasaki, T., Hase, S. Eds. . Springer-Verlag: London, 2008; pp.200-205.
  5. Kusumoto, S., Fukase, K., Fujimoto, Y. Synthesis of Lipopolysaccharide, Peptidoglycan and Lipoteichoic Acid Fragments. In Comprehensive Glycoscience: From Chemistry to Systems Biology, Kamerling, J. P., Boons, G-J., Lee, Y. C., Suzuki, A., Taniguchi, N., Eds.; Elsevier: London, 2007; pp. 685-711.

｜Professional Memberships｜
　　Chemical Society of Japan
　　The Society of Synthetic Organic Chemistry, Japan
　　The Japanese Society of Carbohydrate Research
　　Japanese Society for Chemical Biology
　　Japanese Society for Bacteriology
　　The Biophysical Society of Japan
　　Forum on Biomolecular Chemistry
　　The Kinki Chemical Society Japan
　　American Chemical Society
　　International Endotoxin and Innate Immunity Society

｜Grants (Representative)｜
　　Funding Program for Next Generation World-Leading Researchers(NEXT Program) (2011-)
　　Grant-in-Aid for Scientific Research (B) (2007-2009, 2010)
　　Takeda Science Foundation incentive award in life science field (2009)
　　Japanese Chemical Innovation and Inspection Institute (JCII) Funding Program (2009)
　　JST Adaptable andSeamless Technology transfer Program (A-step) (2009-2010)
　　Naito Foundation Award for Scientific Research on Priority Areas (Chemical Biology) (2008)
　　Funding Program of Institute for Fermentation, Osaka (IFO) (2008-2010)

｜Others｜
　　Japanese Society for the Promotion of Science / Committee member on Grants-in-Aid for Scientific Research（2007- 2008）
　　The Society of Synthetic Organic Chemistry, Japan /Kansa-branch board member（2008-present）
　　Chemical Society of Japan / Kinki-branch board member（2009-present）

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