2022 |2021 |2020 |2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 |

2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001 | 2000 |



Revisiting Glycosylations Using Glycosyl Fluoride by BF3∙Et2O: Activation of Disarmed Glycosyl Fluorides with High Catalytic Turnover.
Manabe, Y.; Matsumoto, T.; Ikinaga, Y.; Tsutsui, Y.; Sasaya, S.; Kadonaga, Y.; Konishi, A.*; Yasuda, M.*; Uto, T.; Dai, C.; Yano, K.; Shimoyama, A.; Matsuda, A.; Fukase, K.* Org. Lett. 2022, 24, 6-10.

Molecular recognition of sialoglycans by streptococcal Siglec-like adhesins: toward the shape of specific inhibitors.
Carluccio, C.; Forgione, R. E.; Bosso, A.; Yokoyama, S.; Manabe, Y.; Pizzo, E.; Molinaro, A.; Fukase, K.; Fragai, M.; Bensing, B. A.; Marchetti, R.*; Silipo A.* RSC Chem. Biol. 2021, 2, 1618-1630

Chemical Synthesis of Sialyl N-Glycans and Analysis of Their Recognition by Neuraminidase.
Shirakawa, A.; Manabe, Y. Marchetti, R.; Yano, K.; Masui, S.; Silipo, A.; Molinaro, A.; Fukase, K. Angew. Chem. Int. Ed. 2021, 60(46), 24686-24693.

Energetics of lipid transport by the ABC transporter MsbA is lipid dependent
Guo, D., Singh, H., Shimoyama, A., Rowe, S., Guffick, C., Noel, T., Fukase, K., Spring, D., van Veen, H.W.*, Communications Biology 2021, 4, 1379.

Chemically Synthesized Alcaligenes Lipid A as an Adjuvant to Augment Immune Responses to Haemophilus Influenzae Type B Conjugate Vaccine
Liu, Z., Hosomi, K., Shimoyama, A., Yoshii, K., Sun, X., Lan, H., Wang, Y., Yamaura, H., Kenneth, D., Saika, A., Nagatake, T., Kiyono, H., Fukase, K., Kunisawa, J.*, Frontiers in Pharmacology 2021, 12, 763657.

Intratumoral administration of astatine-211-labeled gold nanoparticle for alpha therapy
Kato, H.*, Huang, X., Kadonaga, Y., Katayama, D., Ooe, K., Shimoyama, A., Kabayama, K., Toyoshima, A., Shinohara, A., Hatazawa, J., Fukase, K., Journal of Nanobiotechnology 2021, 19, 223.

Lipopolysaccharide derived from the lymphoid-resident commensal bacteria Alcaligenes faecalis functions as an effective nasal adjuvant to augment IgA antibody and Th17 cell responses
Wang, Y., Hosomi, K., Shimoyama, A., Yoshii, K., Nagatake, T., Fujimoto, Y., Kiyono, H., Fukase, K., Kunisawa, J.*, Frontiers in Immunology 2021, 12, 699349.

Lipopolysaccharide from Gut-Associated Lymphoid Tissue-Resident Alcaligenes faecalis: Complete Structure Determination and Chemical Synthesis of its Lipid A
Shimoyama, A., Lorenzo, F.D., Yamaura, H., Mizote, K., Palmigiano, A., Pither, M.D., Speciale, I., Uto, T., Masui, S.,Sturiale, L., Garozzo, D., Hosomi, K., Shibata, N., Kabayama, K., Fujimoto, Y., Silipo, A., Kunisawa, J., Kiyono, H., Molinaro, A., Fukase, K. Angew. Chem. Int. Ed. 2021, in press.

α-Emitting cancer therapy using 211At‐AAMT targeting LAT1.
Kaneda-Nakashima, K., Zhang, Z., Manabe, Y., Shimoyama, A., Kabayama, K., Watabe, T., Kanai, Y., Ooe, K.,Toyoshima, A., Shirakami, Y., Yoshimura, T.; Fukuda, M.; Hatazawa, J.; Nakano, T.; Fukase, K.; Shinohara, A. Cancer Sci., 2021, 112(3), 1132-1140.

Behavior of glycolylated sialoglycans in the binding pockets of murine and human CD22.
Carluccio, D. C., Forgione, R. E.; Montefiori, M.; Civera, M.; Sattin, S.; Smaldone, G.; Fukase, K.; Manabe, Y.; Crocker, P. R.; Molinaro, A.; Marchetti, R.; Silipo, A. iScience, 2021, 24(1), 101998.

Synthesis of ABO blood group antigens and functional glycan display on the cell surface.
Tsutsui, M., Manabe, Y., Kabayama, K., Fukase, K. Arkivoc, 2021, iv, 168-185.

FRET Detects Lateral Interaction between Transmembrane Domain of EGF Receptor and Ganglioside GM3 in Lipid Bilayers.
Nakano M., Hanashima S., Hara T., Kabayama K., Asahina Y., Hojo H., Komura N., Ando H., Nyholm TKM., Slotte JP., Murata M. BBA - Biomembranes 2021, 1863, 183623.


Lipid A-mediated Bacterial-host Chemical Ecology: Synthetic Research of Bacterial Lipid As and Their Development as Adjuvants
Shimoyama, A.*, Fukase, K.*, Molecules 2021, 26(20), 6294.

Recent Advances in the Chemical Biology of N-Glycans.
Shirakawa, A., Manabe, Y., Fukase, K. Molecules, 2021, 26(4), 1040.

Chemical biology study on N-glycans
Manabe, Y. Trends in Glycosci. Glycotechnol. 2021, 33(193), E63-E67.


下山敦史, 深瀬浩一, 化学同人, 2021, 106-114

深瀬浩一, 真鍋良幸, 下山敦史, シーエムシー出版, 2021, 113-121.

Middle Molecular Strategy, Conjugation Strategies for Development of Bioactive Middle Molecules,
Y. Manabe, A. Shimoyama, K. Kabayama, K. Fukase, Springer, 2021, 3-20.



The Role of Toll-Like Receptor 4 in Infectious and Non Infectious Inflammation; Chemically Synthesized TLR4 Ligands, Their Immunological Functions, and Potential as Vaccine Adjuvant,
Shimoyama, A., Fukase, K. Progress in Inflammation Research 2020, 87, 1-19.

Recent advances in self-adjuvanting glycoconjugate vaccines.
Manabe, Y., Chang, T.-C., Fukase, K. Drug Discov. Today Technol. 2020

Concise and Reliable Syntheses of Glycodendrimers via Self-Activating Click Chemistry: A Robust Strategy for Mimicking Multivalent Glycan–Pathogen Interactions.
Farabi, K., Manabe, Y., Ichikawa, H., Miyake, S., Tsutsui, M., Kabayama, K., Yamaji, T., Tanaka, K., Hung, S.-C., Fukase, K. J. Org. Chem. 2020, 85(24), 16014-16023.

Unveiling Molecular Recognition of Sialoglycans by Human Siglec-10.
Forgione, R.E., Di Carluccio, C., Guzmán-Caldentey, J., Gaglione, R., Battista, F., Chiodo, F., Manabe, Y.,Arciello, A.,Del Vecchio, P., Fukase, K., Molinaro, A., Martín-Santamaría, S., Crocker, P.R., Marchetti, R.*, Silipo, A.* iScience 2020, 23(6), 101231.

「Rationale for Translational Research on Targeted Alpha Therapy in Japan —Renaissance of Radiopharmaceuticals Utilizing Astatine-211 and Actinium-225—」 RADIOISOTOPES 69, 329-340 (2020)
Tsuneo Yano, Koki Hasegawa, Tatsuhiko Sato, Mitsuaki Tatsumi, Tadashi Watabe, Yuichiro Kadonaga, Kazuya Kabayama, Koichi Fukase, Akiko Hachisuka, Yoko Hirabayashi, Hirofumi Fujii and Yoshiharu Yonekura 

「アルファ線核医学治療のための薬剤開発の考察(その4) First-in-Human臨 床に向けた要件」
矢野 恒夫, 長谷川 功紀, 佐藤 達彦, 巽 光朗, 渡部 直史, 藤井 博史, 角永 悠一郎, 樺山 一哉, 深瀬 浩一, 米倉 義晴, 蜂須賀 暁子, 平林 容子 医薬品医療機器レギュラトリーサイエンス51, 364 - 377 (2020)

Total Syntheses of C60- and C100-Dolichols
Hirao, K., Ono, R., Manabe, Y., Masui, S.,Atomi, H., Fukase, K., The Journal of Organic Chemistry 2020, 85 (17), 11549-11559

Lymphoid tissue–resident Alcaligenes establish an intracellular symbiotic environment by creating a unique energy shift in dendritic cells.
Hosomi, K., Shibata, N., Shimoyama, A., Uto, T., Nagatake, T., Tojima, Y. Nishino, T., Takeyama, H., Fukase, K., Kiyono, H., Kunisawa, J., Frontiers in Microbiology 2020, 11, 561005.

Chemically synthesized Alcaligenes lipid A shows a potent and safe nasal vaccine adjuvant activity for the induction of Streptococcus pneumoniae-specific IgA and Th17 mediated protective immunity.
Yoshii, K., Hosomi, K., Shimoyama, A., Wang, Y., Yamaura, H., Nagatake, T., Suzuki, H., Lan, H., Kiyono, H., Fukase, K., Kunisawa, J., Microorganisms 2020, 8(8), 1102.

Adjuvant activity of synthetic lipid A of Alcaligenes, a gut-associated lymphoid tissue-resident commensal bacterium, to augment antigen-specific IgG and Th17 responses in systemic vaccine.
Wang, Y., Hosomi, K., Shimoyama, A., Yoshii, K., Yamaura, H., Nagatake, T., Nishino, T., Kiyono, H., Fukase, K., Kunisawa, J., Vaccines 2020, 20; 8(3): E395.

Immunological Evaluation of Co-Assembling a Lipidated Peptide Antigen and Lipophilic Adjuvants: Self-Adjuvanting Anti-Breast-Cancer Vaccine Candidates.
Aiga T., Manabe Y., Ito K., Chang TC., Kabayama K., Ohshima S., Kametani Y., Miura A., Furukawa H., Inaba H., Matsuura K., Fukase K. Angew. Chem. Int. Ed. Engl. 2020 in press.

Temporal analysis of localization and trafficking of glycolipids.
Arai K., Kanie Y., Kanie O., Fukase K., Kabayama K., Biochem. Biophys. Res. Commun. 2020, in press.

Discrimination of cellular developmental states focusing on glycan transformation and membrane dynamics by using BODIPY-tagged lactosyl ceramide.
Arai K., Ohtake A., Daikoku S., Nagaya S., Suzuki K., Ito Y., Kabayama K., Fukase K., Kanie Y., Kanie O., Org. Biomol. Chem. 2020, 18, 3724-3733.

Homeostatic and pathogenic roles of GM3 ganglioside molecular species in TLR4 signaling in obesity.
Kanoh H., Nitta T., Go S., Inamori K., Veillon L., Nihei W., Fujii M., Kabayama K., Shimoyama A., Fukase K., Ohto U., Shimizu T., Watanabe T., Shindo H., Aoki S., Sato K., Nagasaki M., Yatomi Y., Komura N., Ishida H., Kiso M., Natori Y., Yoshimura Y., Cattaneo A., Letizia M., Ciampa M., Mauri L., Prinetti A., Sonnino S., Suzuki A., Ando H., Inokuchi JI., EMBO J. 2020, e101732.

Deficiency of sphingomyelin synthase 2 prolongs survival by the inhibition of lymphoma infiltration through ICAM-1 reduction.
Taniguchi M., Ueda Y., Matsushita M., Nagaya S., Hashizume C., Arai K., Kabayama K., Fukase K., Watanabe K., Wardhani LO., Hayashi K., Okazaki T., FASEB J. 2020, 34, 3838–3854.

Efficient synthesis of antigenic trisaccharides containing N-acetylglucosamine: protection of NHAc as NAc2.
Tsutsui, M., Sianturi, J., Masui, S., Tokunaga, K., Manabe, Y., Fukase, K., Eur. J. Org. Chem. 2020, 1802-1810.

Structural basis for Glycan-receptor binding by mumps virus hemagglutinin-neuraminidase.
Forgione, R. E., Carluccio, C. C., Kubota, M., Manabe, Y., Fukase, K., Molinaro, A., Hashiguchi, T., Marchetti, R., Silipo, A. Sci. Rep. 2020, 10, 1589.

真鍋良幸、下山敦史、樺山一哉、深瀬浩一、 有機合成化学協会誌、2020, 78 (5), 527-537.

海産天然物 ageladine A の効率合成を基盤とした構造展開と新規活性探索 Efficient Synthesis of Marine Alkaloid Ageladine A and its Structural Modification for Exploring New Biological Activity.
岩田隆之、深瀬浩一、中尾洋一、田中克典、 Journal of Synthetic Organic Chemistry, 2020, 78 (1), 55-63.



The core fucose on an IgG antibody is a n endogenous ligand of Dectin-1.
Manabe, Y., Marchetti, R., Takakura, Y., Nagasaki, M., Nihei, W., Takebe, T., Tanaka, K., Kabayama, K., Chiodo, F., Hanashima, S., Kamada, Y., Miyoshi, E., Dulal, H. P., Yamaguchi, Y., Adachi, Y., Ohno, N., Tanaka, H., Silipo, A., Fukase, K., Molinaro, A., Angew. Chem. Int. Ed. 2019, 58, 18697-18702.

Syntheses and functional studies of self-adjuvanting anti-HER2 cancer vaccines.
Feng, Q., Manabe, Y., Kabayama, K., Aiga, T., Miyamoto, A., Ohshima, S., Kametani, Y., Fukase, K., Chem. Asian. J. 2019, 14, 4268-4273.

Synthesis of Cage-shaped Aluminum Aryloxides: Efficient Lewis Acid Catalyst for Stereoselective Glycosylation Driven by Flexible Shift of Four- to Five-Coordination.
Daiki Tanaka, Yuichiro Kadonaga, Yoshiyuki Manabe, Koichi Fukase, Shota Sasaya, Hikaru Maruyama, Sota Nishimura, Mayu Yanagihara, Akihito Konishi, Makoto Yasuda, Journal of the American Chemical Society, 2019, 141(44) 17466-17471

Activities of the Consortium for Medicine, Chemistry, and Physics at Osaka University.
Kabayama, K., Kaneda, K., Shinohara, A., Shirakami, Y., Watabe, T., Zhang, Z., Toyoshima, A., Yoshimura, T., Manabe, Y., Shimoyama, A., Fukase, K., Journal of Medical Imaging and Radiation Sciences 2019, 50, S1.

Characterisation of the dynamic interactions between complex N-glycans and human CD22.
Carluccio, C. D., Crisman, E., Manabe, Y., Forgione, R. E., Lacetera, A., Amato, J., Pagano B., Randazzo, A., Zampella, A., Lanzetta, R., Fukase, K., Molinaro, A., Crocker, P. R., Martin-Santamaria, S., Marchetti, R., Silipo A., ChemBioChem 2019, 21, 129-140.

Analysis of electrostatic interaction between ganglioside GM3 and transmembrane peptide.
Nimura, Y., Kabayama, K., Asahina, Y., Hanashima, S., Hojo, H., Murata, M., Fukase, K., AIP Conference Proceedings 2019, 2067, 020020.

Elucidation of isoflurane action mechanism on surgical diabetes using microfluidic device.
Arai, K., Kabayama, K., Ono, J., Nakamura, H., Kimura, H., Fukase, K., AIP Conference Proceedings 2019, 2067, 020006.

Development of α-Gal Antibody Conjugates for Increasing Immune Response by Recruiting Natural Antibodies.
Sianturi, J., Manabe, Y., Li, H-S., Chiu, L-T., Chang, T-C., Tokunaga, K., Kabayama, K., Tanemura, M., Takamatsu, S., Miyoshi, E., Hung, S-C., Fukase, K., Angew. Chem. Int. Ed. 2019, in press

Kinetically controlled Fischer glycosidation under flow conditions: A new method for preparing furanosides.
Masui, S., Manabe, Y., Hirao, K., Shimoyama, A., Fukuyama, T., Ryu, I., Fukase, K. Synlett 2019, 30(4),397-400.

Synthesis of Helicobacter pylori peptidoglycan fragments.
Hu, R., Shimoyama, A., Fukase, K., Peptide Science 2019, 2018, in press.

Synthesis And Immunological Evaluation of Self-adjuvanting Anticancer Vaccine Candidate.
Manabe, Y., Chang, T-C., Feng, Q., Fujimoto, Y., Ohshima, S., Kametani, Y., Kabayama, K., Nimura, Y., Lin, C-C., Fukase, K., Peptide Science 2019, 2018, in press.

Single-Step Per-O-Sulfonation of Sugar Oligomers with Concomitant 1,6-Anhydro Bridge Formation for Binding Fibroblast Growth Factors.
Yeh, C.-J., Ku, C.-C., Lin, W.-C., Fan, C.-Y., Zulueta, M.M.L., Manabe, Y., Fukase, K., Li, Y.-K., Hung, S.-C., ChemBioChem 2019, 20(2), 237-240.

ガングリオシドのアシル鎖構造による Toll—like receptor 4 活性化制御メカニズム
狩野裕考,新田昂大,藤居真優,樺山一哉,下山敦史,深瀬浩一,Sandro Sonnino,鈴木明身,井ノ口仁一, エンドトキシン・自然免疫研究 22, 1-7 (2019)

深瀬浩一、東京化学同人、現代化学、2019, 7, 48-53.

深瀬浩一、化学同人、化学、2019, 75 (5), 22-23.

深瀬浩一、ファインケミカル、2019, 48 (1), 5.

深瀬浩一、化学と工業、2019, 72 (2), 114-115.

深瀬浩一、現代化学、2019, 580 (7), 48-53.

矢野恒夫、長谷川功紀、佐藤達彦、蜂須賀暁子、深瀬浩一、平林容子 医薬品医療機器レギュラトリーサイエンス、2019, 50 (3), 122-134.

矢野恒夫、長谷川功紀、角永悠一郎、樺山一哉、小田 敬、上野悟史、蜂須賀暁子、平林容子、深瀬浩一 医薬品医療機器レギュラトリーサイエンス、2019, 50 (12), 749-763.

深瀬浩一、2019, 139, 93-95.



NPC1L1-dependent intestinal cholesterol absorption requires ganglioside GM3 in memAZzzzbrane microdomains.
Nihei, K.I., Nagafuku, W., Hayamizu, M., Odagiri, H., Tamura, Y., Kikuchi, Y., Veillon, Y., Kanoh, L., Inamori, H., Arai, K., Kabayama, K., Fukase, K., Inokuchi, J., Journal of Lipid Research 2018, 59, 2181-2187.

Investigation of novel drug for nuclear medicine targeting to cancer specific amino acid transporter, LAT1
Kaneda, K., Zhang, ZJ. Manabe, Y. , Shimoyama, A., Kabayama, K. , Kanai, Y., Fukase, K., Shinohara, A., CANCER SCIENCE 2018, 109, 606.

Expanding the Applicability of the Metal Labeling of Biomolecules by the RIKEN Click Reaction: A Case Study with Gallium-68 Positron Emission Tomography.
Nakamoto, Y., Pradipta, A.R., Mukai, H., Zouda, M., Watanabe, Y., Kurbangalieva, A., Ahmadi, P., Manabe, Y., Fukase, K., Tanaka, K., ChemBioChem 2018, 19(19), 2055-2060.

Branched sialylated N-glycans are accumulated in brain synaptosomes and interact with Siglec-H.
Handa-Narumi, M., Yoshimura, T., Konishi, H., Fukata, Y., Manabe, Y., Tanaka, K., Bao, G.-M., Kiyama, H., Fukase, K., Ikenaka, K., Cell Struct. Funct. 2018, 43(2), 141-152.

Synthetic Study of N-glycans.
Manabe, Y., Journal of synthetic Organic Chemistry, Japan 2018, 76, 502-505.

Convergent synthesis of a bisecting GlcNAc-containing N-glycan.
Manabe, Y., Shomura, H., Minamoto, N., Nagasaki, M., Takakura, Y., Tanaka, K., Silipo, A., Molinaro, A., Fukase K., Chem. Asian. J. 2018, 13, 1544-1551.

Highly Efficient Coupling of Unstable Bicyclic Pyrimidines and Pyrazoles under Basic Conditions, and its Application to the Synthesis of Pharmaceutical Compounds.
Goi, T., Fukase, K., Synlett 2018, 29(14), 1867-1870.

The NLRP6 Inflammasome Recognizes Lipoteichoic Acid and Regulates Gram-Positive Pathogen Infection.
Hara,H., Seregin, S. S., Yang, D., Fukase, K., Chamaillard, M., Alnemri, E. S., Inohara, N., Chen, G. Y., Núñez, G., Cell 2018, 175(6), 1651-1664.

Synthesis of Cyclopropane Fatty Acids by C(sp3)−C(sp3) Cross-Coupling Reaction and Formal Synthesis of α-Mycolic Acid.
Iwasaki, T., Terahigashi, S., Wang, Y., Tanaka, A., Zhao, H., Fujimoto, Y., Fukase, K., Kambe, N., Advanced Synthesis and Catalysis 2018, 360(19), 3810-3817.

Introduction of 4-Chlorophenyl: A Protecting Group for the Hydroxy Function.
Otsuka, Y., Yamamoto, T., Fukase, K., Synlett 2018, 29(11), 1510-1516.

The second and third amino acids of Pam2 lipopeptides are key for the proliferation of cytotoxic T cells.
Takeda, Y., Azuma, M., Hatsugai, R., Fujimoto, Y., Hashimoto, M., Fukase, K., Matsumoto, M., Seya, T., Innate Immunity 2018, 24(5), 323-331.

Porous nanosheet wrapping for live imaging of suspension cells.
Zhang, H., Aoki, T. , Hatano, K., Kabayama, K. , Nakagawa, M. , Fukase, K. , Okamura, Y., Journal of Materials Chemistry B 2018, 6, 6622-6628.

Syntheses and immunological evaluation of self-adjuvanting clustered N-acetyl and N-propionyl sialyl-Tn combined with a T-helper cell epitope as antitumor vaccine candidates.
Chang, T.C., Manabe, Y., Fujimoto, Y., Ohshima, S., Kametani, Y., Kabayama, K., Nimura, Y., Lin, C.C., Fukase, K., Angewandte Chemie - International Edition 2018, 57, 8219-8224.

Narrower HOMO-LUMO gap attained by conformational switching through peripheral polyarylation in 1,4,5,8-tetraaza-9,10-anthraquinodimethanes.
Suzuki, T., Ishigaki, Y., Sugawara, K., Umezawa, Y., Katoono, R., Shimoyama, A., Manabe, Y., Fukase, K., Fukushima, T., Tetrahedron 2018, 74. 2239-2244.

Time-lapse Monitoring of TLR2 Ligand Internalization with Newly Developed Fluorescence Probes.
Arai, Y., Yokoyama, K., Kawahara, Y., Feng, Q., Ohta, I., Shimoyama, A., Inuki, S., Fukase, K., Kabayama, K., Fujimoto, Y., Org Biomol Chem 2018, 16, 3824-3830.

Bradyrhizobium Lipid a: Immunological Properties and Molecular Basis of its Binding to the Myeloid Differentiation Protein-2/Toll-like receptor 4 complex.
Lembo-Fazio, L., Billod, J.-M., Di Lorenzo, F., Paciello, I., Pallach, M., Vaz Francisco, S., Holgado, A., Beyaert, R., Fresno, M., Shimoyama, A., Fukase, K., Giraud, E., Martín Santamaría, S., Bernardini, M.-L., Silipo, A., Frontiers in Immunology 2018, 9, 1888.

Lymphoid tissue-resident Alcaligenes LPS induces IgA production without excessive inflammatory responses via weak TLR4 agonist activity.
Shibata, N., Kunisawa, J., Hosomi, K., Fujimoto, Y., Mizote, K., Kitayama, N., Shimoyama, A., Mimuro, H. , Sato, S., Kishishita, N., Ishii, K.J., Fukase, K., Kiyono, H., Mucosal Immunology 2018,11, 693-702.

N-結合型糖鎖の合成研究、特集号 天然物化学はおもしろい!
真鍋良幸、有機合成化学協会誌、2018, 76(5), 502-506.

深瀬浩一、ファインケミカル、2018, 47 (12), 5.



Funiculosin variants and phosphorylated derivatives promote innate immune responses via the Toll-like receptor 4/myeloid differentiation factor-2 complex.
Okamoto, N., Mizote, K., Honda, H., Saeki, A., Watanabe, Y., Yamaguchi-Miyamoto, T., Fukui, R., Tanimura, N., Motoi, Y., Akashi-Takamura, S., Kato, T., Fujishita, S., Kimura, T., Ohto, U., Shimizu. T., Hirokawa, T., Miyake, K., Fukase, K., Fujimoto, Y., Nagai, Y., Takatsu, K., J. Biol. Chem. 2017, 292(37), 15378-15394.

A Comprehensive Study of the Interaction between Peptidoglycan Fragments and the Extracellular Domain of Mycobacterium tuberculosis Ser/Thr Kinase PknB.
Wang, Q., Marchetti, R., Prisic, S., Ishii, K., Arai, Y., Ohta, I., Inuki, S., Uchiyama, S., Silipo, A., Molinaro, A., Husson, R.N., Fukase, K., Fujimoto, Y., ChemBioChem, 2017, 18(21), 2094-2098.

Syntheses of N-aryl-protected glucosamines and their stereoselectivity in chemical glycosylations.
Otsuka, Y., Yamamoto, T., Fukase, K., Tetrahedron Lett., 2017, 58(31), 3019-3023.

Synthetic analogs of an Entamoeba histolytica glycolipid designed to combat intracellular Leishmania infection.
Choy, S.L., Bernin, H., Aiba, T., Bifeld, E., Lender, S.C., Mühlenpfordt, M., Noll, J., Eick, J., Marggraff, C., Niss, H., Roldán, N.G., Tanaka, S., Kitamura, M., Fukase, K., Clos, J., Tannich, E., Fujimoto, Y., Lotter, H., Sci. Rep. 2017, 7(1), 9472.

Total Synthesis of Cardiolipins Containing Chiral Cyclopropane Fatty Acids.
Inuki, S., Ohta, I.,Ishibashi, S.,Takamatsu, M., Fukase, K., Fujimoto, Y., J. Org. Chem. 2017, 82(15), 7832-7838.

Synthesis and Functional Studies of Self-Adjuvanting Cancer Vaccine Containing B Cell Epitope Derived from HER2.
Feng, Q., Kabayama, K., Manabe, Y., Miyamoto, A., Kametani, Y., Fukase, K. ,Peptide Science 2017 56-57.

Calcineurin inhibitors exacerbate coronary arteritis via the MyD88 signaling pathway in a murine model of Kawasaki disease.
Murata, K., Motomura, Y., Tanaka, T., Kanno, S., Yano, T., Onimaru, M., Shimoyama, A., Nishio, H., Sakai, Y., Oh-hora, M., Hara, H., Fukase, K. , Takada, H., Masuda, S., Ohga, S., Yamasaki, S., Hara, T., Clinical & Experimental Immunology 2017, 190, 54-67.

ペプチド医薬品のスクリーニング・安定化・製剤化技術 第10章6節 セルフアジュバンティングストラテジーによる合成ワクチン開発
ペプチド医薬品、下山敦史,真鍋良幸,深瀬浩一、技術情報協会、2017, 395-402.

エンドトキシン・自然免疫研究 20~,下山敦史, 藤本ゆかり,深瀬浩一, 隅田恭生他 監修, 医学図書出版, 2017, 20, 15-18.

エンドトキシン・自然免疫研究 20~, 深瀬浩一, 下山敦史, 藤本ゆかり,隅田泰生他 監修, 医学図書出版, 2017, 20, 1-5.

下山敦史, 深瀬浩一、石井 健 監修、シーエムシー出版、2017, Chapter 3, 64-75.

Sugar Synthesis by microfluidic Techniques, Glycochemical Synthesis: Strategies and Applications
Fukase, K., Fujimoto, Y., Tanaka, K., Shimoyama, A., Manabe, Y., Shang-Cheng Hung (Editor), Medel Manuel L. Zulueta (Editor), 2016, Chapter 8, 205-220.

Employing BINOL-phosphoroselenoyl chloride for selective inositol phosphorylation and chemical synthesis of glycosyl inositol phospholipid from Entamoeba histolytica.
Aiba, T., Suehara, S., Choy, SL., Maekawa, Y., Lotter, H., Murai, T., Inuki, S., Fukase, K., Fujimoto, Y. Chem. Eur. J. 2017

Development of α1,6-fucosyltransferase inhibitors through the diversity-oriented syntheses of GDP-fucose mimics using the coupling between alkyne and sulfonyl azide.
Manabe, Y., Kasahara, S., Takakura, Y., Yang, X., Takamatsu, S., Kamada Y., Miyoshi, M., Yoshidome, D., Fukasea, K. Bioorg. Med. Chem.

Flow Dehydration and Hydrogenation of Allylic Alcohols: Application to the Waste-Free Synthesis of Pristane.
Furuta, A., Hirobe, H., Fukuyama, T., Ryu, I., Manabe, Y., Fukase, K. Eur. J. Org. Chem. 2017, (10), 1365-1368.

Product Selectivity of Esterification of L-Aspartic Acid and L-Glutamic Acid Using Chlorotrimethylsilane.
Takaishi, T., Izumi, M., Ota, R., Inoue, C., Kiyota, H., Fukase, K. Natural Product Commun. 2017, 12(2), 247-249.

Synthesis of peptidoglycan fragments from Enterococcus faecalis with Fmoc-strategy for glycan elongation.
Wang, N., Hasegawa, H., Huang, C.-y., Fukase, K., Fujimoto, Y. Chem. Asian J, 2017, 12(1), 27-30.



Discovery of a Novel Scaffold as an Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitor Based on the Pyrrolopiperazinone Alkaloid, Longamide B.
Shiokawa, Z., Kashiwabara, E., Yoshidome, D., Fukase, K., Inuki, S., Fujimoto, Y. ChemMedChem. 2016, 11(24), 2682-2689.

Chemical Synthesis of a Complex-Type N-Glycan Containing a Core Fucose.
Nagasaki, M., Manabe, Y., Minamoto, N., Tanaka, K., Silipo, A., Molinaro, A., Fukase, K. J. Org. Chem. 2016, 81(22), 10600-10616.

Isolated Polar Amino Acid Residues Modulate Lipid Binding in the Large Hydrophobic Cavity of CD1d.
Inuki, S., Aiba, T., Hirata, N., Ichihara, O., Yoshidome, D., Kita, S., Maenaka, K., Fukase, K., Fujimoto, Y. ACS Chem Biol. 2016, 11(11), 3132-3139.

One-Pot Evolution of Ageladine A through a Bio-Inspired Cascade towards Selective Modulators of Neuronal Differentiation.
Iwata, T., Otsuka, S., Tsubokura, K., Kurbangalieva, A., Arai, D., Fukase, K., Nakao, Y., Tanaka, K. Chem. Eur. J. 2016, 22(41):14707-14716.

Characterization of a Novel d-Glycero-d-talo-oct-2-ulosonic acid-substituted Lipid A Moiety in the Lipopolysaccharide Produced by the Acetic Acid Bacterium Acetobacter pasteurianus NBRC 3283.
Hashimoto, M., Ozono, M., Furuyashiki, M., Baba, R., Hashiguchi, S., Suda, Y., Fukase, K., Fujimoto, Y. J. Biol. Chem. 2016, 291(40), 21184-21194.

Regioselective phosphorylation of myo-inositol with BINOL-derived phosphoramidites and its application for protozoan lysophosphatidylinositol.
Aiba, T., Sato, M., Umegaki, D., Iwasaki, T., Kambe, N., Fukase, K., Fujimoto, Y. Org. Biomol. Chem. 2016, 14(28), 6672-6675.

Efficient Synthesis of (-)-Hanishin, (-)-Longamide B, and (-)-Longamide B Methyl Ester through Piperazinone Formation from 1,2-Cyclic Sulfamidates.
Shiokawa, Z., Inuki, S., Fukase, K., Fujimoto, Y. Synlett 2016, 27(4), 616-620.

Preparation of the Pseudo Membrane Glycoprotein Using HaloTag Technology: Novel Approach for the Functional Analysis of the Glycan on Cel Surface.
Miyake, S., Manabe, Y., Shomura, H., Kabayama, K. Yamaji, T. Hanada, K., Fukase, K., Peptide Science 2017, 2016, 215-216.

A Reduction-Based Sensor for Acrolein Conjugates with the Inexpensive Nitrobenzene as an Alternative to Monoclonal Antibody.
Takamatsu, M., Fukase, K., Oka R., Kitazume S., Taniguchi N., Tanaka, K. Sci. Rep. 2016, 6, 35872.

Development of a simple assay system for protein-stabilizing efficiency based on hemoglobin protection against denaturation and measurement of the cooperative effect of mixing protein stabilizers.
Chen, S., Manabe, Y., Minamoto, Y., Saiki, N., Fukase, K., Bioscience, Biotechnology, and Biochemistry 2016, 80(10), 1874-8.

Efficient synthesis of the disialylated tetrasaccharide motif in N-glycan via an amide protection strategy.
Zhou, J., Manabe, Y., Tanaka, K., Fukase, K., Zhou, J., Manabe, Y., Tanaka, K., Fukase, K., Chem. Asian. J. 2016, 11, 1436-1440.

Peptidoglycan Microarray as A Novel Tool to Explore Protein-Ligand Recognition.
Wang, N., Hirata, A., Nokihara, K., Fukase, K., Fujimoto, Y., Biopolymers, 2016, 16.

Synthesis of characteristic Mycobacterium peptidoglycan (PGN) fragments utilizing with chemoenzymatic preparation of meso-diaminopimelic acid (DAP), and their modulation of innate immune responses.
Wang, Q., Matsuo, Y., Pradipta, A.R., Inohara, N., Fujimoto, Y., Fukase, K., Org Biomol Chem., 2016, 14(3), 1013-23.



Synthesis of the Conojugates of Tumor Antigens with Adjuvants for the Efficient Cancer Immunotherapy.
Manabe, Y., Chang, T-C., Li H-S, Terao, N., Takamatsu, S., Tanemura, M., Miyoshi, E., Fukase, K., Peptide Science,2016, 2015, 77-78.

Synthesis and Biofunctional Study of Immunomodulative Lipopolysaccharide Partial Structures.
Shimoyama, A., Mizote, K., Fujimoto, Y., Fukase, K., Glycoconj J, 2015, 32, 173–342.

深瀬浩一, 田中克典, 下山敦史, 日本分子イメージング学会機関誌JSMI report 2015, 8(2), 18-25.

Chemical Approach to a Whole Body Imaging of Sialo-N-Linked Glycans.
Tanaka, K., Fukase, K., Top Curr Chem., 2015, 367, 201-30.

Effective Synthesis of Oligosaccharide under Microfluidic Conditions.
Fukase, K., Shimoyama, A., Manabe, Y., J. Syn. Org. Chem. JPN., 2015, 73 (5), 452-459.



Synthesis and function of Mycobacterium cell wall peptidoglycan (PGN) fragments.
Wang, Q., Matsuo, Y., Fujimoto, Y., Fukase, K. Peptide Science, 2015, 2014, 51st, 17-18.

深瀬浩一、ファルマシア、2014, 50(11), 1091-1095.

Molecular basis for bacterial peptidoglycan recognition by LysM domains.
Mesnage, S., Dellarole, M., Baxter, NJ., Rouget, JB., Dimitrov, JD., Wang, N., Fujimoto, Y., Hounslow, AM., Lacroix-Desmazes, S., Fukase, K., Foster, SJ., Williamson, MP. Nat. Commun. 2014, 5, 4269.

Direct guanylation of amino groups by cyanamide in water: catalytic generation and activation of unsubstituted carbodiimide by scandium(III) triflate.
Tsubokura, K., Iwata, T., Taichi, M., Kurbangalieva, A., Fukase, K., Nakao, Y., Tanaka, K. Synlett, 2014, 25(9), 1302-1306.

Imino [4+4] cycloaddition products as exclusive and biologically relevant acrolein-amine conjugates are intermediates of 3-formyl-3,4-dehydropiperidine (FDP), an acrolein biomarker.
Takamatsu, M., Fukase, K., Kurbangalieva, A., Tanaka, K., Bioorg Med Chem., 2014, 22(22), 6380-6386.

Solid-phase Synthesis of Bacterial Cell Wall Peptidoglycan Fragments.
Kadonaga, Y., Wang, N., Fujimoto, Y., Fukase, K., Chem. Lett., 2014, 43(9), 1461- 1463.

The attenuated inflammation of MPL is due to the lack of CD14-dependent tight dimerization of the TLR4/MD2 complex at the plasma membrane.
Tanimura, N., Saitoh, S., Ohto, U., Akashi-Takamura, S., Fujimoto, Y., Fukase, K., Shimizu, T., Miyake, K., Int. Immunol., 2014, 26(6), 307-314.

Revisiting the bromination of C-H bonds with molecular bromine by using a photo-microflow system.
Manabe, Y., Kitawaki, Y., Nagasaki, M., Fukase, K., Matsubara, H., Hino, Y., Fukuyama, T., Ryu, I., Chem. Eur. J., 2014, 20, 12750-12753.

Efficient glycosylation using in(OTf)3 as a lewis acid: activation of N-phenyltrifluoroacetimidate or thioglycosides with halogenated reagents or PhIO.
Salmasan, R. M., Manabe, Y., Kitawaki, Y., Chang, T.-C., Fukase, K., Chem. Lett., 2014, 43(6), 956-958.

Practical and Efficient Method for α-Sialylation with an Azide Sialyl Donor Using a Microreactor.
Uchinashi, Y., Tanaka, K., Manabe, Y., Fujimoto, Y., Fukase, K., Journal of carbohydrate chemistry, 2014, 33(2), 55-67.

Template-assisted synthesis of phosphorylated protein recognition peptide and its selective tumor growth inhibition.
Fukase, K., Iwata, T., Shirotsuki, S., Kageyama, C., Tahara, T., Nozaki, S., Siwu, E. R. O., Tamura, S., Douke, S., Murakami, N., Onoe, H., Watanabe, Y, Tanaka, K., Peptide Science, 2014, 2013, 43-46.

Bacterial lipopeptides as toll-like receptor 2 (TLR2) ligands; synthesis, function and its application.
Fujimoto, Y., Kajiki, Y., Kawahara, Y., Katsumoto, M., Fukase, K., Peptide Science, 2014, 2013, 41-42.

One-pot synthesis of N-acetyl- and N-glycolylneuraminic Acid capped trisaccharides and evaluation of their influenza a(h1 n1) inhibition.
Hsu, Y., Ma, HH., Lico, LS., Jan, JT., Fukase, K., Uchinashi, Y., Zulueta, MM., Hung, SC., Angew Chem Int Ed Engl., 2014, 53(9), 2413-2416.

A cascading reaction sequence involving ligand-directed azaelectrocyclization and autooxidation-induced fluorescence recovery enables visualization of target proteins on the surfaces of live cells.
Tanaka, K., Kitadani, M., Tsutsui, A., Pradipta, AR., Imamaki, R., Kitazume, S., Taniguchi, N., Fukase, K., Org Biomol Chem., 2014, 12(9), 1412-1418.

The attenuated inflammation of MPL is due to the lack of CD14-dependent tight dimerization of the TLR4/MD2 complex at the plasma membrane.
Tanimura, N., Saitoh, SI., Ohto, U., Akashi-Takamura, S., Fujimoto, Y., Fukase, K., Shimizu, T., Miyake, K., Int Immunol., 2014, Jan 27. [Epub ahead of print]



Development of bis-unsaturated ester aldehydes as amino-glue probes: sequential double azaelectrocyclization as a promising strategy for bioconjugation.
Tanaka, K., Nakamoto, Y., Siwu, ER., Pradipta, AR., Morimoto, K., Fujiwara, T., Yoshida, S., Hosoya, T., Tamura, Y., Hirai, G., Sodeoka, M., Fukase, K., Org Biomol Chem., 2013, 11(42), 7326-7333.

Human SAP is a novel peptidoglycan recognition protein that induces complement-independent phagocytosis of Staphylococcus aureus.
An, JH., Kurokawa, K., Jung, DJ., Kim, MJ., Kim, CH., Fujimoto, Y., Fukase, K., Coggeshall KM, Lee BL., J Immunol., 2013, 191(6), 3319-3327.

Cytotoxic activity of ursolic acid derivatives obtained by isolation and oxidative derivatization.
Mazumder, K., Tanaka, K., Fukase, K., Molecules 2013, 18, 8929-8944.

Synthesis and biological activity of phosphoglycolipids from Thermus thermophilus.
Fujimoto, Y., Mitsunobe, K., Fujiwara, S., Mori, M., Hashimoto, M., Suda, Y., Kusumoto, S., Fukase, K. Org. Bioorg. Chem., 2013, 30 (11), 5034-5041.

Separation and characterization of the immunostimulatory components in unpolished rice black vinegar (kurozu).
Hashimoto, M., Obara, K., Ozono, M., Furuyashiki, M., Ikeda, T., Suda, Y., Fukase, K., Fujimoto, Y., Shigehisa, H. Biosci. Bioeng., 2013, 116 (6), 688-696.

Whole-body imaging of tumor cells by azaelectrocyclization: Visualization of metastasis dependence on glycan structure
Tanaka, K., Moriwaki, K., Yokoi, S., Koyama, K., Miyoshi, E., Fukase, K., Bioorg. Med. Chem., 2013, 21(5), 1074-1077.

Glycan sequence-dependent Nod2 activation investigated with chemically synthesized bacterial peptidoglycan fragment library.
Wang, N., Huang, C.-y., Hasegawa, M., Inohara, N., Fujimoto, Y., Fukase, K.  ChemBioChem, 2013, 14, 482-488.

Peptidoglycan as innate immunomodulator; chemical synthesis of its fragments, immunostimulatory activities, and natural Nod1 ligand structures in the environments/fermented food.
Fujimoto, Y., Pradipta, R. A., Hashimoto, M., Kan, S., Shigehisa, H., Fukase, K., Peptide Science, 2013, 97-98.

A conformationally fixed analog of the peptide mimic Grb2–SH2 domain: synthesis and evaluation against the A431 cancer cell.
Iwata, T., Tanaka, K., Tahara, T., Nozaki, S., Onoe, H., Watanabe, Y, Fukase, K., Mol. BioSyst., 2013, 9, 1019-102.

Innate immunomodulation by lipophilic termini of lipopolysaccharide; synthesis of lipid A from Porphyromonas gingivalis and other bacteria and their immunomodulative response.
Fujimoto, Y., Shimoyama, A., Saeki, A., Kitayama, N., Kasamatsu, C., Tsutsui, H., Fukase, K., Mol. BioSyst., 2013, 9, 987-996.

Nickel-butadiene batalytic system for the cross-coupling of bromoalkanoic acids with alkyl grignard reagents: A practical and versatile method for preparing fatty acids.
Iwasaki, T., Higashikawa, K., Reddy, V. P., Ho, W. W. S., Fujimoto, Y., Fukase, K., Terao, J., Kuniyasu, H., Kambe, N., Chem. Eur. J., 2013, 19, 2956-2960.

深瀬浩一, 藤本ゆかり, 実験医学 第三の生命糖 糖鎖の機能と疾患, 羊土社, 2013, 31 (10), 169-175.



Bio-imaging and cancer targeting with glycoproteins and N-glycans
Fukase, K., Tanaka, K., Curr. Opin. Chem. Biol. (2012), 16(5-6), 614-621.

Structural characterization of neutral and acidic glycolipids from Thermus thermophilus HB8
Suda, Y., Okazaki, F., Hasegawa, Y., Adachi, S., Fukase, K., Kokubo, S., Kuramitsu, S., Kusumoto, S., PLoS One (2012), 7(7), e35067.

Efficient synthesis of 2,6,9-triazabicyclo[3.3.1]nonanes through amine-mediated formal [4+4] reaction of unsaturated imines.
Tanaka, K., Siwu, R. O. E., Hirosaki, S., Iwata, T., Matsumoto, R., Kitagawa, Y., Pradipta, A. R., Okuma, M., Fukase, K., Tetrahedron Lett., 2012, 53, 5899-5902.

Cell surface biotinylation by azaelectrocyclization: Easy-handling and versatile approach for living cell labeling.
Tanaka,K., Yokoi, S., Morimoto, K., Iwata, T., Nakamoto, Y., Nakayama, K., Koyama, K., Fujiwara, T., Fukase, K., Bioorg. Med. Chem., 2012, 20, 1865–1868

Structural basis of species-specific endotoxin sensing by innate immune receptor TLR4/MD-2.
Ohto, U., Fukase, K., Miyake, K., Shimizu, T., Proc. Natl. Acad. Sci. USA, 2012, 109 (19), 7421-7426.

Synthesis and immunomodulatory activities of Helicobacter pylori lipophilic terminus of lipopolysaccharide including lipid A.
Fujimoto, Y., Shimoyama, A., Suda, Y., Fukase, K. Carbohydrate Research, 2012, 356, 37-43

Development of Azaelectrocyclization-Based Labeling and Application to Noninvasive Imaging and Targeting Using N-Glycan Derivatives —In pursuit of N-Glycan Functions on Proteins, Dendrimers, and Living Cells—
アミノ基の高速化学標識に基づく N - 結合型糖鎖の非侵襲的イメージングとターゲティング —糖タンパク質、デンドリマー、および生細胞上の N - 結合型糖鎖の機能解析を目指して—

Tanaka, K., Fukase, K. Trends in Glycoscience and Glycotechnology, 2012, 24 (136), 47-64.

Structural and mechanistic analysis of the membrane-embedded glycosyltransferase WaaA required for lipopolysaccharide synthesis.
Schmidt, H., Hansen, G., Singh, S., Hanuszkiewicz, A., Lindner, B., Fukase, K., Woodard, W.R., Holst, O., Hilgenfeld, R., Mamat, U., Mesters, R. J., Pnas., 2012, 109 (16), 6253-6258.

Peptidoglycan as Nod1 ligand; Fragment structures in the environment, chemical synthesis, and their innate immunostimulation.
Fujimoto, Y., Pradipta, A. R., Inohara, N., Fukase, K., Nat. Prod. Rep. 2012, 29, 568-579.

Auxiliary-directed oxidation of ursolic acid by 'Ru'-porphyrins: chemical modulation of cytotoxicity against tumor cell lines.
Tanaka, K., Mazumder, K., Siwu, E. R. O., Nozaki, Satoshi, Watanabe, Y., Fukase, K., Tetrahedron Lett., 2012, 53, 1756-1759.

田中克典, 深瀬浩一, ここまで進んだバイオセンシング・イメージング, 日本化学会編, 化学同人(京都), 2012, 10, 114-122.

寄生性細菌 H.pylori および P. gingivalis リピドAの化学合成と免疫調節活性
藤本ゆかり, 下山敦史, 佐伯昭典, 來山直弘, 生地哲平, 隅田泰生, 筒井ひろ子, 三宅健介, 深瀬浩一, エンドトキシン・自然免疫研究15、日本エンドトキシン研究会編,医学図書出版株式会社(東京), p7-15, 2012

深瀬浩一, 藤本ゆかり,下山敦史, 田中克典, 有機合成化学協会誌, 2012, 70(2)113-130.

深瀬浩一, 藤本ゆかり, 遺伝子医学MOOK 21  最新ペプチド合成技術とその創薬研究への応用, 木曽義昭 編,メディカルドゥ(大阪)2012, pp. 137-144.

糖鎖機能解明に向けた新規化学修飾反応−糖鎖とリンパ球のin vivo イメージング
深瀬浩一, 田中克典, 実験医学, 羊土社, 2012, 30(7), 156-164.



Template-assisted and self-activating clicked peptide as a synthetic mimic of the SH2 domain.
Tanaka, K., Shirotsuki, S., Kageyama, C., Tahara, T., Nozaki, S., Siwu, E. R. O., Iwata, T., Tamura, S., Douke, S., Murakami, N., Onoe, H., Watanabe, Y.. Fukase, K., ACS Chem. Biol., 2011, 637-644.

Chemical synthesis of Helicobacter pylori lipopolysaccharide partial structures and their selective proinflammatory response.
Shimoyama, A., Saeki, A., Tanimura, N., Tsutsui, H., Miyake, K.,Suda, Y., Fujimoto, Y., Fukase. K., Chem. Eur. J. 2011, 17, 14464-14474.

Reinvestigation of the C5-Acetamide Sialic Acid Donor for a-Selective Sialylation: Practical Procedure under Microfluidic Conditions
Uchinashi, Y., Nagasaki, M., Zhou, J., Tanaka, K., Fukase, K., Org. Biomol. Chem., 2011, 9, 7243-7248.

Target-selective and fluorescence “switch-on” protein labeling by 6π-azaelectrocyclization
Tanaka, K., Kitadani, M., Fukase, K., Org. Biomol. Chem., 2011, 9, 5346-5349.

Stereoselective glycosylation of 3-deoxy-D-manno-2-octulosonic acid (Kdo) with batch and microfluidic methods.
Shimoyama, A., Fujimoto, Y., Fukase. K., Synlett 2011, 16, 2359-2362.

Ursolic acid derivatives from Bangladeshi medicinal plant, Saurauja roxburghii: Isolation and cytotoxic activity against A431 and C6 glioma cell lines.
Mazumder, K., Siwu, R. O. E., Nozaki, S., Watanabe, Y., Tanaka, K., Fukase, K., Phytochem. Lett., 2011, 4, 287-291.

Exploring a unique reactivity of 6π-azaelectrocyclization to enzyme inhibition, natural products synthesis, and molecular imaging: an approach to chemical biology by synthetic chemists.
Tanaka, K., Fukase, K., Katsumura, S., Synlett, 2011, 15, 2115-2139.

Structures, synthesis, and human Nod1 stimulation of immunostimulatory bacterial peptidoglycan fragments in the environment
Fujimoto, Y., Fukase, K., J. Nat. Prod. 2011, 74(3), 518-525.

Nod1 ligands induce site-specific vascular inflammation.
Nishio, H., Kanno, S., Onoyama, S., Ikeda, K., Tanaka, T., Kusuhara, K., Fujimoto, Y., Fukase, K., Sueishi, K. Hara, T., Arterioscler. Thromb. Vasc. Biol., 2011, 31, 1093-1099.

Failure of mycoplasma lipoprotein MALP-2 to induce NK cell activation through dendritic cell TLR2.
Sawahata, R., Shime, H., Yamazaki, S., Inoue, N., Akazawa, T., Fujimoto, Y., Fukase, K., Matsumoto, M., Seya, T., Microbes Infect. 2011, 13, 350-358.

Oligosaccharide Synthesis on Solid, Soluble Polymer, and Tag Supports.
K. Tanaka, K. Fukase, In Solid-Phase Organic Synthesis Book, P. Toy (ed), John Wiley & Sons, New Jersey, 2011, 489-530.

深瀬浩一, 田中克典, 蛍光イメージング/MRIプローブの開発, シーエムシー出版, 2011, 35-43.

藤本ゆかり, 深瀬浩一, アジュバント開発研究の新展開, シーエムシー出版, 2011, 66-73.

田中克典, 深瀬浩一, 月刊未来材料, 解説Review, エヌ・ティー・エス, 2011, 11(5), 11-19.

マイクロ経路内および固相上での効率的グリコシル化反応を基盤としたN-結合型糖タンパク質糖鎖のライブラリー指向型合成Library-Directed Solid-Phase and Microfluidic Synthesis of N-Linked Glycans
田中克典, 深瀬浩一,「特集 糖鎖合成の発展と最新応用研究」月刊ファインケミカル, シーエムシー出版, 2011, 40 (5), 23-30

田中克典, 深瀬浩一,次世代バイオ医薬品の製剤設計と開発戦略, シーエムシー出版, 2011, 119-126.



Asymmetric synthesis of 14C-labeled L-Proparagylglycine.
Kurosawa, M., Tanaka, K., and Fukase, K., Radioisotopes, 2010, 59(12), 17-22.

Noninvasive Imaging of Dendrimer-Type N-Glycan Clusters: In Vivo Dynamics Dependence on Oligosaccharide Structure.
Tanaka, K., Siwu, E. R. O., Minami, K., Hasegawa, K., Nozaki, S., Kanayama, Y., Koyama, K., Chen, W. C., Paulson, J. C., Watanabe, Y., Fukase, K., Angew. Chem. Int. Ed. 2010, 49 (44), 8195-8200.

Probe design and synthesis of Galβ(1→3)[NeuAcα→6)]GlcNAcβ(1→2)Man motif of N-glycan.
Bao, GM., Tanaka, K., Ikenaka, K., Fukase, K., Bioorg Med Chem. 2010 Jun 1;18(11):3760-3766.

Self and Nonself Recognition with Bacterial and Animal Glycans, Surveys by Synthetic Chemistry.
Fujimoto, Y., Tanaka, K., Shimoyama, A., Fukase, K., Methods Enzymol. 2010;478:323-342.

The peptide sequence of diacyl lipopeptides determines dendritic cell TLR2-mediated NK activation.
Azuma, M., Sawahata, R., Akao, Y., Ebihara, T., Yamazaki, S.,Matsumoto, M., Hashimoto, M., Fukase, K., Fujimoto, Y., Seya, T.,PLoS One. 2010 Sep 2;5(9). pii: e12550.

Characterization of natural human nucleotide-binding oligomerization domain protein 1 (NOD1) ligands from bacterial culture supernatant for elucidation of immune modulators in the environment.
Pradipta, A. R., Fujimoto, Y., Hasegawa, M., Inohara, N., Fukase, K., J. Biol. Chem. 2010, 285 (31), 23607-23613.

A combined 6p-azaelectrocyclization/staudinger approach to protein & cell engineering: non-invasive tumor targeting by N-Glycan-engineered lymphocytes.
Tanaka, K., Minami, K.,Tahara, T., Siwu, E. R. O., Koyama, K., Nozaki, S., Onoe, H., Watanabe, Y., Fukase, K., J. Carbohydr. Chem. 2010, 29(3), 118-132

Electrocyclization-based labeling allows efficient in vivo imaging of cellular trafficking.
Tanaka, K., Minami, K., Tahara, T., Fujii, Y., Siwu, E. R. O., Nozaki, S., Onoe, H., Yokoi, S., Koyama, K., Watanabe, Y., Fukase, K., ChemMedChem, 2010 (5), 841-845.

New strategy in synthetic biology:from enzyme inhibition and natural products synthesis to PET imaging by 6π-azaelectrocyclization.
Tanaka, K., Fukase, K., Katsumura, S., The Chemical Record, 2010, 10, 119-139.

Key structures of bacterial peptidoglyan and lipopolysaccharide triggering the innate immune system of higher animals: Chemical synthesis and functional studies.
Kusumoto, S., Fukase, K., and Shiba T., Proc. Jpn. Acad., Ser. B, 2010, 86 (4), 322-337.

Structural prerequisites for endotoxic activity in the Limulus test as compared to cytokine production in mononuclear cells.
Gutsmann, T., Howe, J., Zahringer, U., Garidel, P., Schromm, A. B., Koch, M.H., Fujimoto, Y., Fukase, K., Moriyon, I., Martinez-de-Tejada, G., Brandenburg, K., Innate Immun. 2010, 16(1), 39-47

Nucleotide oligomerization binding domain-like receptor signaling enhances dendritic cell-mediated cross-priming in vivo.
Asano, J., Tada, H., Onai, N., Sato, T., Horie, Y. Fujimoto, Y. Fukase, K., Suzuki, A., Mak, W. T., and Ohteki, T., J. Immunol., 2010, 184 (2), 736-745.

Multimeric bivalent immunogens from recombinant tetanus toxin Hc fragment, synthetic hexasaccharides, and a glycopeptide adjuvant.
Bongat, F. G. A., Saksena, R., Adamo, R., Fujimoto, Y., Shiokawa, Z., Peterson, C. D.,  Fukase, K., Vann, F. W., and Kovac, P., Glycoconj. J., 2010, 27, 69-77.

Widely Applicable Deprotection Method of 2,2,2-Trichloroethoxycarbonyl (Troc) Group Using Tetrabutylammonium Fluoride
Huang, C., Wang, N., Fujiki, K., Otsuka, Y., Akamatsu, M., Fujimoto, Y., Fukase, K., J. Carbohydr. Chem. 2010, 29 (6), 289-298.

深瀬浩一,藤本ゆかり,下山敦史,田中克典, 有機合成化学協会誌, 70(2)113-130 (2012)

田中克典、深瀬浩一、ここまで進んだバイオセンシング・イメージング、日本化学会編、化学同人(京都)、2012, 10, 114-122.

藤本ゆかり、未来材料、エヌ・ティー・エス、2012, 12 (11), 13-21.

寄生性細菌 H.pylori および P. gingivalis リピドAの化学合成と免疫調節活性
藤本ゆかり、下山敦史、佐伯昭典、來山直弘、生地哲平、隅田泰生、筒井ひろ子、三宅健介、深瀬浩一, エンドトキシン・自然免疫研究15、日本エンドトキシン研究会編,医学図書出版株式会社(東京), p7-15, 2012

深瀬浩一、藤本ゆかり, 遺伝子医学MOOK 21  最新ペプチド合成技術とその創薬研究への応用, 木曽義昭 編,メディカルドゥ(大阪)2012, pp. 137-144

糖鎖機能解明に向けた新規化学修飾反応−糖鎖とリンパ球のin vivo イメージング
深瀬浩一、田中克典、実験医学、羊土社、2012, 30(7), 156-164

田中克典, 深瀬浩一、生体の科学、[特集]糖鎖のかかわる病気、(財)金原一郎記念医学医療振興財団/医学書院、2010, 61 (2) 173-180.

In Vivo Imaging and Targeting by Oligosaccharides and Related Molecules

田中克典, 深瀬浩一, 第三の生命鎖「糖鎖」を活用・制御するケミカルバイオロジー, 月刊バイオインダストリー, シーエムシー出版, 2010, 27 (2), 29-36.

Nonivasive imaging of glycans

田中克典, 深瀬浩一, 遺伝子医学MOOK, 株式会社 メディカル ドゥ, 2010, 18, 66-73.

田中克典, 深瀬浩一, 「化学フロンティア2010: 生命現象を理解する分子ツール最前線-イメージングから生体機能解析まで」化学同人, 2010, 22, 54-62.



Traceless solid-phase synthesis of multiple sulfonamide-containing cyclic sulfides exploiting microwave irradiation.
Saruta, K., Ogiku, T., Fukase, K. Tetrahedron Lett., 2009, 50, 4364-4367

Acid-mediated reactions under micro-fluidic conditions: a new strategy for practical synthesis of bio-functional natural products.
Tanaka, K., Fukase, K., Beilstein, K., Journal of Organic Chemistry-Thematic series “Flow Chemistry” 2009, 5, No.40.

Chemistry-based labeling and engineering on proteins and cell surfaces: application to Non-invasive imaging of oligosaccharide derivatives
Tanaka, K., Minami, K., Siwu, E. R. O., Fukase, K., Chemical Biology (Japanese Society for Chemical Biology) 2009, 2, 7-12.

Lipopeptides from staphylococcus aureus as Tlr2 ligands: prediction with mRNA expression, chemical synthesis, and immunostimulatory activities.
Fujimoto, Y., Hashimoto, M., Furuyashiki, M., Katsumoto, M., Seya, T., Suda, Y., Fukase, K, ChemBioChem, 2009, 10(14), 2273-2403.

Chemical synthesis of bacterial lipid A.
Kusumoto, S., Fukase, K., Fujimoto, Y., Microbial Glycobiology, 2009, 415-427

Library-directed Solution- and Solid-phase Synthesis of 2,4-Disubstituted Pyridines: One-pot Approach through 6.pi.-Azaelectrocyclization.
Sakaguchi, T., Kobayashi, T., Hatano, S., Tsuchikawa, H., Fukase, K., Tanaka, K., and Katsumura, S., Chemistry--An Asian Journal, 2009, 4(10), 1573-1577.

Lipopeptides from Staphylococcus aureus as Tlr2 Ligands: Prediction with mRNA Expression
Fujimoto, Y., Hashimoto, M., Furuyashiki, M., Katsumoto, M., Seya, T., Suda, Y., and Fukase, K., ChemBioChem, 2009, 10(14), 2311-2315.

Renaissance of Traditional Organic Reactions under Microfluidic Conditions: A New Paradigm for Natural Products Synthesis.
Tanaka, K., Fukase, K..,Organic Process Research & Development, 2009, 13(5), 983-990.

WaaA of the hyperthermophilic bacterium aquifex aeolicusis a monofunctional 3-deoxy-D--oct-2-ulosonic acid transferase involved in lipopolysaccharide biosynthesis.
Mamat, U., Schimdt, H., Munoz, E., Lindner, B., Fukase, K., Hanuszkiewicz., Wu, J., Meredith, T. C., Woodard, R. W., Hilgenfeld, R., Mesters, J. R., and Holst, O., J. Biol. Chem., 2009, 284 (33), 22248-22262.

Chemical N-glycosylation by asparagine under integrated microfluidic/batch conditions.
Tanaka, K., Miyagawa, T., and Fukase, K., Synlett, 2009, 10, 1571-1574.

Synthesis of crosslinked peptidoglycan fragments for investigation of their immunobiological functions.
Fujimoto, Y., Konishi, Y., Kubo, O., Hasegawa, M., Inohara, N., and Fukase, K., Tetrahedron Lett., 2009, 50, 3631-3634.

Characterization of N-terminal structure of TLR2-activating lipoprotein in staphylococcus aureus.
Tawaratsumida, K., Furuyashiki, M., Katsumoto, M., Fujimoto, Y., Fukase, K., Suda, Y., and Hashimoto, M., J. Biol. Chem., 2009, 284, 9147-9152.

Synthesis of a sialic acid containing complex-type N-glycan on a solid support.
Tanaka, K., Fujii, Y., Tokimoto, H., Mori, Y. Tanaka, S. Bao, G., Siwu, E. R. O., Nakayabu, A., and Fukase, K., Chem. Asian J., 2009, 4, 574-580.

Synthesis and immunostimulatory activities of lipopeptides from Gram-positive bacteria.
Katsumoto, M., Fujimoto, Y., Furuyashiki, M., Hashimoto, M., Suda, Y., and Fukase, K., Peptide Science 2008, 155-156. (2009).

Practical synthesis of a manβ(1-4)GlcNTroc fragment via microfluidic β-mannosylation.
Tanaka, K., Mori, Y., and Fukase, K., J. Carbohydr. Chem., 2009, 28 (1), 1-11.

Chemical synthesis of bacterial lipid A.
Kusumoto, S., Fukase, K., Fujimoto, Y., In Microbial Glycobiology: Structures, Relevance and Applications, Anthon Moran, Otto Holst, Patrick J Brennan, Mark von Itzstein Eds. Elsevier: London, 2009; pp.415-427.

藤本ゆかり, 生命化学研究レタ ー, FBC Lett., 2009, 31, 4-9.

糖鎖のインビボバイオイメージン グ
田中克典, 深瀬浩一, 株式会社シーエム シー出版, 正田晋一郎, 稲津敏行監修, 複合糖質の化学と最新応用技術, 2009, 235-244.

Synthesis and biofunctional studies of bacterial immunostimulating glycoconjugates.
Fukase. K., and Fujimoto, Y., “Progress in the Synthesis of Complex Carbohydrate Chains of Plant and Microbial Polysaccharides”, ed. By Nikolay E. Nifantiev, Transworld Research Network (Kerala, 2009), 279-308.



Synthesis of diaminopimelic acid containing peptidoglycan fragments and tracheal cytotoxin (TCT) and investigation of their biological functios.
Kawasaki, A., Karasudani, Y., Otsuka, Y., Hasegawa, M., Inohara, N., Fujimoto, Y., and Fukase, K., Chem. Eur. J., 2008, 14, 10318-10330.

Autophagic control of listeria through intracellular innate immune recognition in drosophila.
Yano, T., Mita, S., Ohmori, H., Oshima, Y., Fujimoto, Y., Ueda, R., Takada, H., Goldman, E., W., Fukase, K., Silverman, N., Yoshimori, T., and Kurata S., Nat. Immunol., 2008, 9 (8), 908-916.

A new catch-and-release purification method using a levulinyl group as a tag and its application to oligosaccharide synthesis.
Izumi, M., Okamoto, R., Sato, M., Nakajima, S., Baba, N., and Fukase, K., Chem. Lett., 2008, 37 (10), 1030-1031.

Site-selective and nondestructive protein labeling through azaelectrocyclization-induced cascade reactions.
Tanaka, K., Fujii, Y., and Fukase, K., Chem. Bio. Chem., 2008, 9, 2392-2397.

Recent advances in positron emission tomography (PET) imaging of biomolecules: form chemical labeling to cancer diagnostics.
Tanaka, K., and Fukase, K.,, Mini-reviews in Organic Chemistry, 2008, 5, 153-162.

Efficient aldol condensation in aqueous biphasic system under microfluidic conditions
Tanaka, K., Motomatsu, S., Koyama, K., and Fukase, K., Tetrahedron Lett., 2008, 49, 2010-2012.

Autophagic control of listeria through intracellular innate immune recognition in drosophila.
Yano, T., Mita, S., Ohmori, H., Oshima, Y., Fujimoto, Y., Ueda, R., Takada, H., Goldman, W. E., Fukase, K, Silverman, N., Yoshimori, T., and Kurata, S., Nat. Immunol. 2008, 9, 908-916.

Synthesis of Rubrivivax gelatinosus lipid A and analogues for investigation of the structural basis for immunostimulating and inhibitory activities
Fukase, Y., Fujimoto, Y., Adachi, Y., Suda, Y., Kusumoto, S., Fukase, K., Bull. Chem. Soc. Jpn., 2008, 81, 796-819.

A critical role of RICK/RIP2 polyubiquitination in Nod-induced NF-κB activation.
Hasegawa, M., Fujimoto, Y., Lucas, P. C., Nakano, H., Fukase, K., Nunez, and G., Inohara, N., EMBO J. 2008, 27(2), 373-383.

Differential activation of human TLR4 by escherichia coli and shigella flexneri 2a lipopolysaccharide: combined effects of lipid A acylation state and TLR4 polymorphisms on signaling.
Rallabhandi, P., Awomoyi, A., Thomas, E. K., Phalipon, A., Fujimoto, Y., Fukase, K., Kusumoto, S., Qureshi, N., Szteinm B. M., and Vogel, N. S., J. Immunol. 2008, 180(2), 1139-1147.

PET (positron emission tomography) imaging of biomolecules using metal-DOTA complexes: a new collaborative challenge by chemists, biologists, and physicians for future diagnostics and exploration of in vivo dynamics.
Tanaka, K., Fukase, K., Org. Biomol. Chem., 2008, 6, 815-828.

A submicrogram scale protocol for biomolecule-based PET imaging by rapid 6π-azaelectrocyclization: visualization of sialic acid dependent circulatory3 residence of glycoproteins.
Tanaka, K., Masuyama, T., Hasegawa, K., Tahara, T., Mizuma, H., Wada, Y., Watanabe, Y., and Fukase, K., Angew. Chem. Int. Ed., 47, 2008, 102-105.

Synthesis of meso-diaminopimelic acid for construction of Gram-negative bacterial peptidoglycan partial structures.
Kawasaki, A., Karasudani, Y., Inohara, N., Fujimoto, Y., and Fukase, K., Peptide Science, 2007, 121-122.(2008)

Acceleration of Cu(I)-mediated huisgen 1,3-dipolar cycloaddition by histidine derivatives: library synthesis of “self-activating” click peptides.
Tanaka, K., Kageyama, C., Shirotsuki, S., and Fukase, K., Peptide Science, 2007, 171-174.(2008)

Molecular cloning and functional characterization of porcine nucleotide-binding oligomerization domain-1 (NOD1) recognizing minimum agonists, meso-diaminopimelic acid and meso-lanthionine.
Tohno, M., Shimazu, T., Aso, H., Uehara, A., Takada, H., Kawasaki, A., Fujimoto, Y., Fukase, K., Saito, T., and Kitazawa, H., Mol. Immunol., 2008, 45, 1807-1817.

New labeling method of biomolecules via rapid azaelectrocyclization: application to PET imaging.
Tanaka, K., Masuyama, T., Minami, K., Fujii, Y., Hasegawa, K., Tahara, T., Mizuma, H., Wada, Y., Watanabe, Y., and Fukase, K., Peptide Science, 2007, 91-94.(2008)

Polymer-supported and tag-assisted methods in oligosaccharide synthesis.
Tanaka, K., and Fukase, K., Glycoscience (2008)

Combinatorial methods on oligosaccharide synthesis.
Tanaka, K., Fujimoto., Y. Tanaka, S., Mori, T., and Fukase, K., Glycoscience (2008)

Efficient synthesis of oligosaccharides and synthesis of pathogen-associated molecular patterns for their biofunctional studies.
Fukase, K., Fujimoto, Y., Tanaka, K., “Experimental Glycoscience”, eds. by Taniguchi et al. Springer-Verlag (Berlin 2008), 200-205.

深瀬浩一, 藤本ゆかり, 化学, 化学同人, 63 (9), 30-36 (2008)



Expression of various Toll-like receptors, NOD1, and NOD2, in human oral epithelial cells, and their function.
Sugawara, Y., Uehara., A. Fujimoto, Y., Fukase, K., Sasano T., and Takada, H., Interface Oral Health Science, 2007, 225-230.

Synthesis of lipopolysaccharide, peptidoglycan, and lipoteichoic acid fragments.
Kusumoto, S., Fukase, K., and Fujimoto, Y., "Comprehensive Glycoscience Vol. 1", eds. by G.-J. Boons, Y. C. Lee, A. Suzuki., N. Taniguchi, and A. G. J. Voragen, Elsevier (U.S.A., 2007), p. 685-711

Highly efficient α-salylation by virtue of fixed dipole effects of N-phthalyl group: application to continuous flow synthesis of α(2-3)- and α(2-6)-Neu5Ac-Gal motifs by microreactor.
Tanaka, S., Goi, T., Tanaka, K., and Fukase, K., J. Carbohydr. Chem. 2007, 26, 369-394

Synthesis of immunoregulatory Helicobacter pylori lipopolysaccharide partial structures.
Fujimoto, Y., Iwata, M., Imakita, N., Shimoyama, A., Suda, Y., Kusumoto, S., and Fukase, K., Tetrahedron Lett. 2007, 48 (37), 6577-6581

Acceleration of Cu(I)-mediated huisgen 1,3-dipolar cycloaddition by histidine derivatives.
Tanaka, K. Kageyama, C., and Fukase, K., Tetrahedron Lett. 2007, 48 (37), 6475-6479

Chemicals synthess of peptidoglycan fragments for elucidation of the immunostimulating mechanism.
Fujimoto, Y., Inamura S., Kawasaki, A., Shiokawa, Z., Shimoyama, A., Hashimoto T., Kusumoto, S., and Fukase, K., J. Endotoxin Res. 2007, 13 (3), 189-196

Nod1/RICK and TLR signaling regulate chemokine and antimicrobial innate immune responses in mesothelial cells1
Park, J.-H., Kim, Y.-G., Shaw, M., Kanneganti, T.D., Fujimoto, Y., Fukase. K., Inoara, N., and Nunez, G, J. Immunol. 2007, 179 (1), 514-521

Crystal structures of human MD-2 and its complex with antiendotoxic lipid IVa.
Ohto, U., Fukase, K., Miyake, K. and Satow, Y., Science 2007, 316, 1632-1634

A role of lipophilic peptidoglycan-related molecules in induction of Nod1-mediated immune responses.
Hasegawa, M., Kawasaki, A., Yang, K., Fujimoto, Y., Masumoto J., Breukink, E., Nunez, G., Fukase, K., and Inohara, N., J Biol Chem. 2007, 282 (16), 11757-11764

Differential modulation of nods signaling pathways by fatty acids in human colonic epithelial HCT116 cells.
Zhao, L., Kwon, M.J., Huang, S., Lee, J.Y., Fukase, K., Inohara, N., and Hwang, D.H., J Biol Chem. 2007, 282 (16), 11618-11628

Evidence of immunostimulating lipoprotein existing in natural lipoteichoic acid fraction.
Hashimoto, M., Furuyashiki, M., Kaseya, R., Fukada, Y., Akimaru, M., Aoyama, K., Okuno, T., Tamura, T., Kirikae, T., Kirikae, F., Eiraku, N., Morioka, H., Fujimoto, Y., Fukase, K., Takashige, K. Moriya, Y.,Kusumoto, S., and Suda, Y., Infect. Immun. 2007, 75 (4), 1926-1932

Inhibition of lipid A-mediated type I interferon induction by bactericidal/permeability-increasing protein (BPI).
Azuma, M., Matsuo, A., Fujimoto, Y., Fukase, K., Hazeki, K., Hazeki, O., Matsumoto, M., and Seya, T., Biochem. Biophys. Res. Commun. 2007, 354, 574-578

Large-scale synthesis of immunoactivating natural product, pristane, by continuous microfluidic dehydration as the key step.
Tanaka, K., Motomatsu, S., Koyama, K., Tanaka, S., and Fukase, K., Org. Lett. 2007, 9 (2), 299-302

Joint meeting of the society for Leukocyte Niology and the International Endotoxin and Innate Immunity Society, “Innate Immunity:Receptors, Regulation, and Response” November 9-11,2006, San Antonio, Texas
深瀬浩一, 「感染・炎症・免疫」東京, 医薬の門社, 37 (2), 69-70, 2007



Synthesis of fluorescent probe for intracellular innate immune receptor Nod1.
Shimoyama, A., Kawasaki, A., Inohara, N., Fujimoto, Y, and Fukase, K., Peptide Science 2006, 155

Synthesis of potent immunostimulating Nod1 ligands: acylated diaminopimelic acid containing peptides.
Kawasaki, A., Fujimoto, Y., Inohara, N., and Fukase, K., Peptide Science 2006, 156

Synthesis of endotoxic principle of bacterial lipopolysaccharide and its recognition by the innate immune systems of hosts.
Kusumoto, S., and Fukase, K., Chem. Rec. 2006, 6, 333-343

Recombinant soluble forms of extracellular TLR4 domain and MD-2 inhibit lipopolysaccharide binding on cell surface and dampen lipopolysaccharide-induced pulmonary inflammation in mice.
Misuzawa, H., Nishitani, C., Hyakushima, N., Shimizu, T., Sano, H., Matsushima, N., Fukase, K., and Kuroki, Y., J. Immunol. 2006, 177 (11), 8133-8139

Synthesis and biological activities of biscarboxymethyl lipid A analogues.
Kataoka, M., Hashimoto, M., Suda, Y., Kusumoto, S., and Fukase, K., Heterocycles 2006, 69, 395-415

Mannose-binding lectin Augments the uptake of lipid A, Staphylococcus aureus, and Escherichia coli by kupffer cells through increased cell surface expression of scavenger receptor A1.
Ono, K., Nishitani, C., Mitsuzawa, H., Shimizu, T., Sano, H., Suzuki, H., Kodama, T., Fujii, N., Fukase, K., Hirata, K., and Kuroki, Y., J. Immunol. 2006, 177 (8), 5517-5523

Virulence factors of Yersinia pestis are overcome by a strong lipopolysaccharide response.
Montminy, S.W., Khan, N., McGrath, S., Walkowicz, M.J., Sharp, F., Conlon, J.E., Fukase, K., Kusumoto, S., Sweet, C., Miyake, K., Akira, S., Cotter, R.J., Goguen, J.D., and Lien, E., Nat. Immunol., 7, 1066-1073, (2006).

Sarcoidosis and NOD1 variation with impaired recognition of intracellular Propionibacterium acnes.
Tanabe, T., Ishige, I., Suzuki, Y., Aita, Y., Furukawa, A., Ishige, Y., Uchida, K., Suzuki, T., Takemura, T., Ikushima, S., Oritsu, M., Yokoyama, T., Fujimoto, Y., Fukase, K., Inohara, N., Nunez, G., and Eishi, Y., Biochim. Biophys. Acta. 2006, 1762, 794-801

Differential release and distribution of Nod1 and Nod2 immunostimulatory molecules among bacterial species and environments.
Hasegawa, M., Yang, K., Hashimoto, M., Park, J.-H., Kim, Y.-G., Fujimoto, Y., Nunez, G., Fukase, K., and Inohara, N., J. Biol. Chem. 2006, 281 (39), 29054-29063

Synthesis of lipid A monosaccharide analogues containing acidic amino acid: Exploring the structural basis for the endotoxic and antagonistic activities
Akamatsu, M., Fujimoto, Y., Kataoka, M., Suda, Y., Kusumoto, S., and Fukase, K., Bioorg. Med. Chem. 2006, 14, 6759-6777

Regulatory roles for MD-2 and TLR4 in ligand-induced receptor clustering.
Kobayashi, M., Saitoh, S., Tanimura, N., Takahashi, K., Kawasaki, K., Nishijima, M., Fujimoto, Y., Fukase, K., Akashi-Takamura, S., and Miyake, K., J. Immunol. 2006, 176 (10), 6211-6218

Toll-like receptors, NOD1 and NOD2, in oral epithelial cells.
Sugawara, Y., Uehara, A., Fujimoto, Y., Kusumoto, S., Fukase, K., Shibata, K., Sugawara, S., Sasano, T., and Takada, H., J. Dent. Res. 2006, 85 (6), 524-529

A synthetic peptidoglycan fragment as a competitive inhibitor of the melanization cascade.
Park, J. W., Je, B-R., Piao,, S., Inamura, S., Fujimoto, Y., Fukase, K,. Kusumoto, S., Soderhall, K., Ha, N.-C., and Lee, B. L., J. biol. Chem. 2006, 281 (12), 7747-7755

Nod1 acts as an intracellular receptor to stimulate chemokine production and neutrophil recruitment in vivo.
Masumoto, J., Yang, K., Varambally, S., Hasegawa, M., Tomlins, S. A., Qui, S., Fujimoto, Y., Kawasaki, A., Foster, S. J., Horie, Y., Mak, T. W., Nunez, G., Chinnaiyan, A. M., Fukase, K., and Inohara, N., J. Exp. Med. 2006, 203 (1), 203-213

Biologically active lipid A antagonist embedded in a multilayered polyelectrolyte architecture.
Gangloff, S. C., Ladam, G., Dupray, V., Fukase, K., Brandenburg, K., Guenounou, M., Schaaf, P., Voegel, J.-C., and Jessel, N., Biomaterials 2006, 27, 1771-1777

Synthesis and bioactivity of fluorescence- and biotin-labeled lipid A analogues for investigation of recognition mechanism in innate immunity.
Fujimoto, Y., Kimura, E., Murata, S., Kusumoto, S., and Fukase, K., Tetrahedron Lett. 2006, 47 (4), 539-543

Synthesis of peptidoglycan fragments and evaluation of their biological activity.
Inamura, S., Fujimoto, Y., Kawasaki, A., Shiokawa, Z., Woelk, E., Heine, H., Lindner, B., Inohara, N., Kusumoto, S., and Fukase, K., Org. Biomol. Chem. 2006, 4 (2), 232-242

受容体機能の制御を指向したリ ピドAの合成と生物活性
藤本ゆかり, 隅田泰生, 楠本正一, 瀬浩一「エンドトキシン研究9」, 熊沢義雄 監修, 医学図書出版株式会社(東京), 2006



Separation of S-form lipopolysaccharide with resins having branched tri-lysine, a putative phosphate recognition sequence.
Goi, T., Fujimoto, Y., and Fukase, K., Peptide Science 2005, 433-436.

Human peptidoglycan recognition protein S is an effector of neutrophil-mediated innate immunity.
Cho, J. H., Fraser, I. P., Fukase, K., Kusumoto, S., Fujimoto, Y., Stahl, G.L., and Ezekowitz, R. A. B., Blood, 2005, 106 (7), 2551-2558

Synthesis of lipid A and its analogues for investigation of the structural basis for their bioactivity.
Fujimoto, Y., Adachi, Y., Akamatsu, M., Fukase, Y., Kataoka, M., Suda, Y., Fukase, K., and Kusumoto, S., J. Endotoxin Res. 2005, 11 (6), 341-347

Highly efficient sialylation towards α(2-3)- and α(2-6)-Neu5Ac-Gal synthesis: significant ‘fixed dipole effect’ of N-Phthalyl group on α-selectivity.
Tanaka, K., Goi, T., and Fukase, K., Synlett, 2005 (19), 2958-2962.

Oligosaccharide synthesis by affinity separation based on molecular recognition between podand ether and ammoniumi on.
Fukase, K. Takashina, M., Hori, Y., Tanaka, D., Tanaka, K., and Kusumoto, S., Synlett, 2005 (15), 2342-2346.

Highly β-selective mannosylation towards manβ1-4GlcNAc synthesis: TMSB(C6F5)4 as a lewis acid/cation trap catalyst
Tanaka, S., Takashina, M., Tokimoto, H., Fujimoto, Y., Tanaka, K., and Fukase, K., Synlett, 2005 (15), 2325-2328.

New deprotection method of the 2,2,2-trichloroethoxycarbonyl (Troc) group with (Bu3Sn)2.
Tokimoto, H., and Fukase, K., Tetrahedron Lett. 2005, 46 (40), 6831-6832

Dendritic cell maturation induced by muramyl dipeptide (MDP) derivatives: monoacylated MDP confers TLR2/TLR4 activation.
Uehori, J., Fukase, K., Akazawa, T., Uematsu, S., Akira, S., Funami, K., Shingai, M., Matsumoto, M., Azuma, I., Toyoshima, K., Kusumoto, S., and Seya, T., J. Immunol. 2005, 174 (11), 7096-7103

Chlorotrimethylsilane as a mild and effective source of acid catalyst in reductive benzylation
Izumi, M., and Fukase, K., Chem. Lett. 2005, 34 (4), 594-595

Stereoselective glycosylation using the long-range effect of a [2-(4-phenylbenzyl)oxycarbonyl]benzoyl group.
Tokimoto, H., Fujimoto, Y., Fukase, K., and Kusumoto, S., Tetrahedron Asymmetry 2005, 16, 441-447.

Physicochemical characterization of carboxymethyl lipid A derivatives in relation to biological activity.
Seydel, U., Schromm, A. B., Brade, L., Gronow, S., Andra, J., Muller, M., Koch, M. H. J., Fukase, K., Kataoka, M., Hashimoto, M., Kusumoto, S., and Brandenburg, K., FEBS J. 2005, 272, 327-340.

深瀬浩一「固相合成ならびに固相-液相のハイブリッド法による糖鎖の迅速合成」谷口直之,伊藤幸成監修,エヌ・ティー・エス刊行(東京), (2005.8.19)p.393-399




Solid-phase synthesis of indol-2-ones by microwave-assisted radical cyclization.
Akamatsu, H., Fukase, K., and Kusumoto, S., Synlett 2004 (6), 1049-1053.

NMR conformational analysis of biosynthetic precursor-type lipid A: monomolecular state and supramolecular assembly.
Oikawa, M., Shintaku, T., Fukuda, N., Sekljic, H., Fukase, Y., Yoshizaki, H., Fukase, K., and Kusumoto, S., Org. Biomol. Chem. 2004, 2 (24), 3557-3565

Ligand-dependent toll-like receptor 4 (TLR4)-oligomerization is directly linked with TLR4-signaling.
Saitoh, S., Akashi, S., Yamada, T., Tanimura, N., Matsumoto, F., Fukase, K., Kusumoto, S., Kosugi, A., and Miyake, K., J. Endotoxin Res. 2004, 10 (4), 257-260

Lipid A antagonist, lipid IVa, is distinct from lipid A in interaction with Toll-like receptor 4 (TLR4)-MD-2 and ligand-induced TLR4 oligomerization.
Saitoh, S., Akashi, S., Yamada, T., Tanimura, N., Kobayashi, M., Konno, K., Matsumoto, F., Fukase, K., Kusumoto, S., Nagai, Y., Kusumoto, Y., Kosugi, A., and Miyake, K., International Immun. 2004, 16 (7), 961-969

Monomeric and polymeric gram-negative peptidoglycan but not purified LPS stimulate the drosophila IMD pathway.
Kaneko, T., Goldman, W.-E., Mellroth, P., Steiner, H., Fukase, K., Kusumoto, S., Harley, W., Fox, A., Golenbock, D., and Silverman, N., Immunity 2004, 20, 637-649

Combinational clustering of receptors following stimulatinon by bacterial products determines lipopolysaccharide responses.
Triantafilou, M., Brandenburg, K., Kusumoto, S., Fukase, K., Mackie, A., Seydel, U., and Triantafilou, K., Biochem. J. 2004, 381, 527-536

Aggregates are the biologically active units of endotoxin
Mueller, M., Lindner, B., Kusumoto, S., Fukase, K., Schromm, A.-B., and Seydel, U., J. Biol. Chem. 2004, 279 (25), 26307-26313

Mechanism of immunostimulating action of peptidoglycan, investigation with synthetic partial structures.
Fukase, K., Inamura, S., Kawasaki, A., Fujimoto, Y., Kusumoto, S., Inoharam, N., and Nunez, G., Peptide Science 2004, 109-112.



Solid-phase synthesis of a phytoalexin elicitor pentasaccharide using a 4-azido-3-chlorobenzyl group as the key for temporary protection and catch-and release purification.
Egusa, K., Kusumoto, S., and Fukase, K., Eur. J. Org. Chem. 2003, 3435-3445.

Structural basis for endotoxic and antagonistic activities: investigation with novel synthetic lipid A analogs.
Kusumoto, S., Fukase, K., Fukase, Y., Kataoka, M., Yoshizaki, H., Sato, K., Oikawa, M., and Suda, Y., J. Endotoxin Res. 2003, 9 (6), 361-366

Lipopolysaccharide interaction with cell surface Toll-like receptor 4-MD-2: Higher affinity than that with MD-2 or CD14.
Akashi, S., Saitoh, S., Wakabayashi, Y., Kikuchi, T., Takamura, N., Nagai, Y., Kusumoto, Y., Fukase, K., Kusumoto, S., Adachi, Y., Kosugi, A., and Miyake, K., J. Exp. Med. 2003, 198 (7), 1035-1042

Cell activation by monosaccharide lipid A analogues utilizing Toll-like receptor 4.
Tamai, R., Asai, Y., Hashimoto, M., Fukase, K., Kusumoto, S., Ishida, H., Kiso, M., and Ogawa, T., Immunol. 2003, 110 (1), 66-72

A dominant role of Toll-like receptor 4 in the signaling of apoptosis in bacteria-faced macrophages.
Haase, R., Kirschning, C. J., Sing, A., Schrottner, P., Fukase, K., Kusumoto, S., Wagner, H., Heesemann, J., and Ruckdeschel, K., J. Immunol. 2003, 171 (8), 4294-4303

Endotoxic and immunobiological activities of a chemically synthesized lipid A of Helicobacter pylori strain 206-1.
Ogawa, T., Asai, Y., Sakai, Y., Oikawa, M., Fukase, K., Suda, Y., Kusumoto, S., and Tamura, T., FEMS Immunol. Med. Microbiol. 2003, 36, 1-7

Synthesis and biological activities of lipid A analogs possessing β-glycosidic linkage at 1-position.
Fukase, K., Ueno, A., Fukase, Y., Oikawa, M., Suda, Y., and Kusumoto, S., Bull. Chem. Soc. Jpn. 2003, 76 (3), 485-500

Host recognition of bacterial muramyl dipeptide mediated through NOD2.
Inohara, N., Ogura, Y., Fontalba, A., Gutierrez, O., Pons, F., Crespo, J., Fukase, K., Inamura, S., Kusumoto, S., Hashimoto, M., Foser, S. J., Moran, A. P., Fernandez-Luna, J. L., and Nunez, G., J. Biol. Chem. 2003, 278 (8), 5509-5512

Human peptidoglycan recognition protein-L is an N-acetylmuramoyl-L-alanine amidase.
Wang, Z-M., Li, X., Cocklin, R. R., Wang, M., K. Fukase, K., Inamura, S., Kusumoto, S., Gupta, D., and Dziarski, R., J. Biol. Chem. 2003, 278 (49), 49044-49052

An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid.
Chamaillard, M., Hashimoto, M., Horie, Y., Masumoto, J., Qiu, S., Saab, L., Ogura, Y., Kawasaki, A., Fukase, K., Kusumoto, S., Valvano, M. A., Foster, S. J., Mak, T. W., Nunez, G., and Inohara, N., Nat. Immunol. 2003, 4 (7), 702-707

深瀬浩一,深瀬嘉之,楠本正一,「エンドトキシン研究6」,日本エンドトキシン研究会編,医学図書出版, (2003), p. 43-52.



Synthetic chemistry and function of bacterial cell surface glycoconjugates.
Kusumoto, S., Fukase, K., Oikawa, M., and Suda, Y., J. Chin. Chem. Soc. 2002. 49 (4), 453-458

Reactivity switching on solid support: solid-phase synthesis of tertiary amines by reduction of tertiary amides with LiAIH4.
Akamatsu, H., Kusumoto, S., and Fukase, K., Tetrahedron Lett. 2002, 43 (49), 8867-8869

New efficient route for solid-phase synthesis of benzimidazole derivatives.
Akamatsu, H., Fukase, K., and Kusumoto, S., J. Comb. Chem. 2002, 4 (5), 475-483

Solid-phase synthesis of oligosaccharides using novel alkyne-type linkers: selection of
reactive sites on the support by Sonogashira reaction.
Izumi, M., Fukase, K., and Kusumoto, S., Synlett, 2002 (9), 1409-1416.

Chemical synthesis of cyclodextrins by using intramolecular glycosylation.
Wakao, M., Fukase, K., and Kusumoto, S., J. Org. Chem. 2002, 67 (23), 8182-8190

A direct continuous spectrophotometric assay for glycosidases with 3-nitro-2-pyridyl glycosides by tautomerization of 2-hydroxy-3-nitropyridine.
Ma, S.-J., Hiratake, J., Nakai, Y., Izumi, M., Fukase, K., Kusumoto, S., and Sakata, K., Anal. Biochem. 2002, 302, 291-297

TMSCI as a mild and effective source of acidic catalysis in fischer glycosidation and use of propargyl glycoside for anomeric protection.
Izumi, M., Fukase, K., and Kusumoto, S., Biosci. Biotechnol. Biochem. 2002, 66 (1), 211-214



Chemoenzymatic synthesis of a trisaccharide-serine conjugate, Gal(β1-3)Gal(β1-4) Xyl(β1-O)-L-Ser, use of galactosyl fluoride as a donor for transglycosylation.
Fukase, K., Yasukochi, T., and Kusumoto, S., Bull. Chem. Soc. Jpn. 2001. 74 (6), 1123-1128

Human MD-2 confers on mouse Toll-like receptor 4 species-specific lipopolysaccharide recognition.
Akashi, S. Nagai, Y., Ogata, H., Oikawa, M., Fukase, K., Kusumoto, S., Kawasaki, K., Nishijima, M., Hayashi, S., Kimoto, M., and Miyake, K., International Immun. 2001, 13 (12), 1595-1599

New efficient route for synthesis of lipid A by using affinity separation.
Fukase, Y., Zhang, S.-Q., Iseki, K., Oikawa, M., Fukase, K., and Kusumoto, S., Synlett 2001, (11), 1693-1698.

A new catch-and-release purification method using a 4-azido-3-chlorobenzyl group.
Egusa, K., Kusumoto, S., and Fukase, K., Synlett 2001, (6), 777-780.

Synthesis based on affinity separation (SAS): separation of products having barbituric acid tag from untagged compounds by using hydrogen bond interaction.
Zhang, S.- Q., Fukase, K., Izumi, M., Fukase, Y., and Kusumoto, S., Synlett 2001, (5), 590-596.

Synthesis of [3H]-labeled bioactive lipid A analogs and their use for detection of lipid A-binding proteins on murine macrophages.
Fukase, K., Kirikae, T., Kirikae, F., Liu, W-C., Oikawa, M., Suda, Y., Kurosawa, M., Fukase, Y., Yoshizaki, H., and Kusumoto, S., Bull. Chem. Soc. Jpn. 2001, 74 (11), 2189-2197

Conformational study of a tetraacyl biosynthetic precursor of lipid A by NMR.
Oikawa, M., Shintaku, T., Yoshizaki, H., Fukase, K., Adachi, S., Lee, K., and Kusumoto, S., Bull. Chem. Soc. Jpn. 2001, 74 (8), 1455-1461

First total synthesis of the Re-type lipopolysaccharide.
Yoshizaki, H., Fukuda, N., Sato, K., Oikawa, M., Fukase, K., Suda, Y.. and Kusumoto, S., Angew. Chem. Int. Ed. 2001, 40 (8), 1475-1480

Synthetic study of peptidoglycan partial structures. Synthesis of tetrasaccharide and octasaccharide fragments.
Inamura, S., Fukase K., and Kusumoto, S., Tetrahedron Lett. 2001, 42 (43), 7613-7616



Identification of branched peptidic structures that recognize immunostimulating glycoconjugate lipid A from encoded combinatorial libraries.
Fukase, K., Wakao, M., Izumi, M., Ueno, A., Oikawa, M., Suda, Y., Kusumoto, S., Nestler, H. P., Sherlock, R., and Liu, R., Peptide Science 2000, 365-368

Toll-like receptor 4 imparts ligand-specific recognition of bacterial lipopolysaccharide.
Lien, E., Means, T. K., Heine, H., Yoshimura, A., Kusumoto, S., Fukase, K., Fenton, M. J., Oikawa, M., Qureshi, N., Monks, B., Finberg, R. W., Ingalls, R. R., and Golenbock, D. T., J. Clinic, Invest. 2000, 105 (4), 497-504

Lipopolysaccharide-binding protein-mediated interaction of lipid A from different origin with phospholipid membranes.
Gustmann, T., Schromm, A. B., Koch, M. H. J., Kusumoto, S., Fukase, K., Oikawa, M., Seydel, U., and Brandenburg, K., Phys. Chem. Chem. Phys. 2000, 2, 4521-4528

Synthesis of Helicobacter pylori lipid A and its analogue using p-(trifluoromethyl)benzyl protecting group.
Sakai, Y., Oikawa, M., Yoshizaki, H., Ogawa, T., Suda, Y., Fukase, K., and Kusumoto, S., Tetrahedron Lett. 2000, 41 (35), 6843-6847

Conformational studies on a unique bis-sulfated glycolipid using NMR spectroscopy and molecular dynamics simulations.
Tanaka, N., Fukase, K., Utsumi, H., and Ishizuka, I., Eur. J. Biochem. 2000, 267 (10), 6790-6797

Intrinsic conformation of lipid A is responsible for agonistic and antagonistic activity.
Seydel, U., Oikawa, M., Fukase, K., Kusumoto, S., and Brandenburg, K., Eur. J. Biochem. 2000, 267 (10), 3032-3039

Stereoselective glycosylation and oligosaccharide synthesis on solid support using a 4-azido-3-chlorobenzyl group for temporary protection.
Egusa, K., Fukase, K., Nakai, Y., and Kusumoto, S., Synlett 2000 (1), 27-32



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