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Middle-size biomolecules (MW ca. 400-4000) such as natural products, glycans, peptides, nucleic acid drug, and etc. have high chemical diversity and various biological activities.
In this research project, middle-size molecule strategy will be promoted by three stages: development of novel bio-functional middle molecules (A01), achievement of highly efficient synthesis of bioactive middle molecules (A02), and evolution of reaction integration (A03).