Publications


2011

  1. Y. Kajihara, S. Nishigaki, D. Hannzawa, G. Nakanishi, R. Okamoto, N. Yamamoto, Unique self-anhydride formation in the degradation of Cytidine-5'-mono-phospho-sialic acid (CMP-Neu5Ac) and Cytidine-5'-di-phospho-sialic acid (CDP-Neu5Ac) and its application CMP-sialic acid analogue synthesis, Chem. Eur. J. in press.

2010

  1. K. Hirano, Y. Kajihara, Synthesis of Heavily Glycosylated Peptide α-Thioester. J. Carbohydr. Chem., (2010) 29(2), 84-91.

  2. T. Murase, Y. Kajihara, Synthesis of glycosylated polypeptide chain of inducible costimulator on T cell. Carbohydr. Res., (2010) 345(10), 1324-1330..

  3. N. Kamei, R. Fukui, Y. Suzuki, Y. Kajihara, M. Kinoshita, K. Kakehi, H. Hojo, K. Tezuka. T. Tsuji, Definitive evidence that a single N-glycan among three glycans on inducible costimulator is required for proper protein trafficking and ligand binding. Biochem.Biophys. Res. Commun., (2010) 391, 557-563..

  4. R.Okamoto, M. Izumi, Y. Kajihara, Expanding the scope of native chemical ligation in glycopeptides synthesis. Int. J. Pept. Res. Ther., (2010) 16, 191-198..

  5. Y. Kajihara, N. Yamamoto, R. Okamoto, K. Hirano, T. Murase, Chemical synthesis of homogeneous glycopeptides and glycoproteins. Chemical Record, (2010) 10, 80-100.

  6. Y. Kajihara, R. Okamoto, N. Yamamoto, M. Izumi, Synthesis of Glycopeptides. Methods in Enzymology, (2010) 478, 503-519 Editor: Minoru Fukuda, Academic Press.

  7. Mine, T.; Kajiwara, H.; Murase, T.; Kajihara Y.; Yamamoto, T. An α2,3-Sialyltransferase from Photobacterium sp. JT-ISH-224 Transfers N-Acetylneuraminic Acid to Both the O-2 and O-3' Hydroxyl Groups of Lactose, J. Carbohydr. Chem., 2010, 29, 51-60.

2009

  1. K. Hirano, D. Macmillan, K. Tezuka, T. Tsuji, Y. Kajihara Design and Synthesis of Homogeneous Erythropoietin Analogue with Two Human Complex-Type Sialyloligosaccharides: Combined Use of Chemical and Bacterial Protein Expression Methods. Angew. Chem. Int. Ed., (2009), 48,9557-9560. Selected for Inside cover as well as hot paper.

  2. N.Nagahara, T. Matsumura, R. Okamoto, Y. Kajihara, Protein cysteine modifications: (2) Reactivity Specificity and Topics of Medical Chemistry and Protein Engineering.Curr. Med. Chem., (2009), 16, 4490-4501.

  3. N.Nagahara, T. Matsumura, R. Okamoto, Y. Kajihara, Protein cysteine modifications: (1) Medical chemistry for proteomics. Curr. Med. Chem., (2009)16:4419-4444.

  4. T. Murase, T. Tsuji, Y. Kajihara; Efficient and systematic synthesis of a small glycoconjugate library having human complex type oligosaccharides. Carbohydr. Res., 344, (2009), 762-770.

  5. R. Okamoto, S. Souma, Y. Kajihara; Efficient Substitution Reaction from Cysteine to the Serine Residue of Glycosylated Polypeptide: Repetitive Peptide Segment Ligation Strategy and the Synthesis of Glycosylated Tetracontapeptide Having Acid Labile Sialyl-TN Antigens. J. Org. Chem., (2009), 74 , 2494-2501.

2000～2008

  1. R. Okamoto, Y. Kajihara; Uncovering latent ligation site for glycopeptide synthesis. Angew. Chem. Int. Ed. (2008), 47(29), 5402-5406.

  2. R. Okamoto, S. Souma, Y. Kajihara; Efficient Synthesis of MUC4 Sialylglycopeptide through the New Sialylation Using 5-Acetamido-Neuraminamide Donors. J. Org. Chem. (2008), 73(9), 3460-3466.

  3. K. Sato, S. Akai, H. Shoji, N. Sugita, S. Yoshida, Y. Nagai, K. Suzuki, Y. Nakamura, Y. Kajihara, M. Funabashi, J. Yoshimura; Stereoselective and Efficient Total Synthesis of Optically Active Tetrodotoxin from D-Glucose. J. Org. Chem. (2008), 73(4), 1234-1242.

  4. N. Yamamoto, Y. Tanabe, R. Okamoto, P. E. Dawson, Y. Kajihara; Chemical Synthesis of a Glycoprotein Having an Intact Human Complex-Type Sialyloligosaccharide under the Boc and Fmoc Synthetic Strategies. J. Am. Chem. Soc. (2008), 130(2), 501-510.

  5. T. Sakakibara, T. Suganuma, Y. Kajihara; Preparation of 2-deoxy-2-C-p-tolylsulfonyl-b -D-glucopyranosyl p-tolyl sulfones having non-chair conformation and their elimination reactions. Chem. Commun. (2007), (34), 3568-3570.

  6. Y. Kajihara, T. Kamitani, R. Sato, N. Kamei, T. Miyazaki, R. Okamoto, T. Sakakibara, T. Tsuji, T. Yamamoto; Synthesis of CMP-9''-modified-sialic acids as donor substrate analogues for mammalian and bacterial sialyltransferases. Carbohydr. Res. (2007), 342(12-13), 1680-1688.

  7. T. J. Hogenauer, Q. Wang, A. K. Sanki, A. J. Gammon, C. H. L. Chu, C. M. Kaneshiro, Y. Kajihara, K. Michael; Virtually epimerization-free synthesis of peptide-a -thio-esters. Org. Biomol. Chem. (2007), 5(5), 759-762.

  8. K. Yamada, T. Yamazaki, M. Asanuma, H. Hirota, N. Yamamoto, Y. Kajihara; Solid-state 17O NMR in biological solids: efficient 17O labeling of amino acids and peptides. Chem. Lett. (2007), 36(1), 192-193.

  9. N. Yamamoto, A. Takayanagi, A. Yoshino, T. Sakakibara, Y. Kajihara; An approach for a synthesis of asparagine-linked sialylglycopeptides having intact and homogeneous complex-type undecadisialyloligosaccharides. Chem. Eur. J. (2007), 13(2), 613-625.

  10. Y. Nishi, N. Yamamoto, K. Shimazaki, N. Takahashi-Ando, H. Kakinuma, S. Jialin, S. N. Ruzheinikov, T. A. Muranova, D. W. Rice, Y. Kajihara; Mechanistic analysis of the phosphonate transition-state analogue-derived catalytic and non-catalytic antibody. J. biochem. (2007), 142(4), 421-433.

  11. Y. Kajihara, N. Yamamoto, A. Yoshihara, A. Takayanagi, K. Hirano; An approach for the chemical synthesis of glycoprotein having homogeneous complex type sialyloligosaccharides. Peptide Science (2006), 43rd 27-28.

  12. Y. Kajihara, A. Yoshihara, K. Hirano, N. Yamamoto; Convenient synthesis of a sialylglycopeptide-thioester having an intact and homogeneous complex-type disialyl-oligosaccharide. Carbohydr. Res. (2006), 341(10), 1333-1340.

  13. N. Yamamoto, A. Takayanagi, T. Sakakibara, P. E. Dawson, Y. Kajihara; Highly efficient synthesis of sialylglycopeptides overcoming unexpected aspartimide formation during activation of Fmoc-Asn(undecadisialyloligosaccharide)-OH. Tetrahedron Lett. (2006), 47(8), 1341-1346.

  14. H. Yuasa, T. Izumi, N. Mitsuhashi, Y. Kajihara, H. Hashimoto; An improvement in the bending ability of a Hinged trisaccharide with the assistance of a sugar-sugar interaction. Chem. Eur. J. (2005), 11(22), 6478-6490

  15. H. Sato, Y. Kajihara; An unambiguous assignment method by 2D selective-TOCSY-HSQC and selective-TOCSY-DQFCOSY and structural analysis by selective-TOCSY-NOESY experiments of a biantennary undecasaccharide. Carbohydr. Res. (2005), 340(3), 469-479.

  16. Y. Kajihara, N. Yamamoto, T. Miyazaki, H. Sato; Synthesis of Diverse Asparagine Linked Oligosaccharides and Synthesis of Sialylglycopeptide on Solid Phase. Curr. Med. Chem. (2005), 12(5). 527-550.

  17. Y. Kajihara; Synthesis of diverse asparagine linked oligosaccharides. Journal of Applied Glycoscience (2005), 52(2), 177-182.

  18. M. Izumi, O. Tsuruta, Y. Kajihara, S. Yazawa, H. Yuasa, H. Hashimoto; Synthesis and evaluation of 5-thio-L-fucose-containing oligosaccharide. Chem. Eur. J. (2005), 11(10), 3032-3038.

  19. Y. Kajihara, Y. Suzuki, N. Yamamoto, K. Sasaki,T. Sakakibar, R. R. Juneja; Prompt Chemoenzymatic Synthesis of Diverse Complex Type Oligosaccharides and its Application to the Solid Phase Synthesis of a Glycopeptide Having Asn-linked Sialyl-undeca and Asialo-nonasaccharides. Chem. Eur. J. (2004), 10, 971-985.

  20. N. Yamamoto, T. Sakakibara, Y. Kajihara; Convenient synthesis of a glycopeptide analogue having a complex type disialyl-undecasaccharide. Tetrahedron Lett. (2004), 45(16), 3287-3290.

  21. E. Inagaki, Y. Ukita, M. Kumei, Y. Kajihara, T. H. Tahirov; Crystallization and preliminary crystallographic analysis of 2-keto-3-deoxygluconate kinase from Thermus thermophilus. Acta Crystallographica, Section D: Biological Crystallography (2004), D60(4), 761-763.

  22. S. Kakuda, T. Shiba, M. Ishiguro, H. Tagawa, S. Oka, Y. Kajihara, T. Kawasaki, S. Wakatsuki, R. Kato;Structural Basis for Acceptor Substrate Recognition of a Human Glucuronyltransferase, GlcAT-P, an Enzyme Critical in the Biosynthesis of the Carbohydrate Epitope HNK-1. J. Biol. Chem. (2004), 279(21), 22693-22703.

  23. Y. Kajihara, D. Kamiyama, N. Yamamoto, T. Sakakibara, M. Izumi, H. Hashimoto; Synthesis of 2-[(2-pyridyl)amino]ethyl b-D-lactosaminide and evaluation of its acceptor ability for sialyltransferase: a comparison with 4-methylumbelliferyl and dansyl b-D-lactosaminide. Carbohydr. Res. (2004), 339(8), 1545-1550.

  24. K. Fukae, N. Yamamoto, Y. Hatakeyama, Y. Kajihara; Chemoenzymatic synthesis of diverse asparagine-linked a -(2,3)-sialyloligosaccharides. Glycoconjugate J. (2004), 21(5), 243-250.

  25. H. Sato, Y. Kajihara; 2D Selective-TOCSY-DQFCOSY Experiment for Identification of Individual Sugar Components in Oligosaccharides. J. Carbohydr. Chem. (2003), 22, 339-345.

  26. T. Sakakibara, K. Suzuki, A. Sakai, M. Shindo, C. Nagano, S. Narumi, Y. Kajihara, K. Mochizuki; .Preparation and structural determination of methyl 3-C-p-tolylsulfonyl-2-C-p-tolylthio-b-d-glucopyanoside derivatives and their 5a-carba-dl-analogs having non-chair conformation in solutions. Tetrahedron Lett. (2003), 44, 5711-5714.

  27. N. Yamamoto, Y. Ohmori, T. Sakakibara, K. Sasaki, L. R. Juneja, Y. Kajihara; Solid-phase synthesis of sialylglycopeptides through selective esterification of the sialic acid residues of an asn-linked complex-type sialyloligosaccharide. Angew. Chem. Int. Ed. (2003), 42, 2537-2540.

  28. K. Okazaki, S. Nishigaki, F. Ishizuka, Y. Kajihara, S. Ogawa; Potent and specific sialyltransferase inhibitors: imino-linked 5a'-carbadisaccharides. Org. Biomol. Chem. (2003), 1, 2229-2230.

  29. Y. Kajihara, Y. Suzuki, K. Sasaki, L. R. Juneja; Chemoenzymatic synthesis of diverse asparagine-linked oligosaccharides. Methods In Enzymology (2003), 362, 44-64.

  30. Y. Kajihara, H. Sato:Strucural Analysis of Oligosaccharides by Nuclear Magnetic Resonance Methods. Trends in Glycoscience and Glycotechnology (2003), 15, 197-220.

  31. S. Akai, Y. Kajihara, Y. Nagashima, M. Kamei, J. Arai, M. Bito, K. Sato; Synthesis of new glycopolymers containing b-D-mannopyranose, and C-2-substituted b-D-mannopyranose residues as a new class of inhibitor. J. Carbohydr. Chem. (2001), 20(2), 121-143.

  32. Y. Kajihara, T. Kamitani, T. Sakakibara; A new fluorescent assa for sialyltransferase. Carbohydr. Res. (2001), 331, 455-459.

  33. A. Kuboki, T.Ishihara, E. Kobayashi, H.. Ohta, T. Ishii, A. Inoue, S. Mitsuda, T. Miyazaki, Y. Kajihara, T. Sugai; Synthesis of Regioselectively Protected Forms of Cytidine Based on Enzyme-catalyzed Deacetylation. Biosci. Biotechnol. Biochem. (2000), 64, 363-368.

  34. Y. Kajihara, H. Hashimoto, S. Ogawa; Galactosyl Transfer Ability of b-(1,4)-Galactosyltransferase Toward 5a-Carba-sugars. Carbohydr. Res. (2000), 323, 44-48.

  35. T. Miyazaki, H. Sato, T. Sakakibara, Y. Kajihara; An Approach for the Precise Chemoenzymatic Synthesis of 13C-Labeled Sialyloligosaccharide on an Intact Glycoprotein: A Novel One-Pot [3-13C]-Labeling Method for Sialic Acid Analogues by Control of the Reversible Aldolase Reaction, Enzymatic Synthesis of [3-13C]-NeuAc-a-(2,3)-[U-13C]-Gal-b-(1,4)-GlcNAc-b- Sequence onto Glycoprotein, and its Conformational Analysis by developed NMR Techniques. J. Am. Chem. Soc. (2000), 122, 5678-5694.

  36. T. Sakakibara, M. Shindo, S. Narumi, C. Nagano, Y. Kajihara; Double Bond Migration of a 1,5-Anhydro-3-C-p-tolylsulfonyl-D-hex-2-enitol Derivative and the Corresponding 5a-Carba-DL-sulfonyl Sugar. J. Carbohydr. Chem. (2000), 19, 783-788.
    1991年～1999年

  37. T. Miyazaki, T. Sakakibara, H. Sato, Y. Kajihara; Chemoenzymatic Synthesis of the 9-Deoxy-9-fluoro-[3-13C]-NeuAc-a-(2,6)-[U-13C]-Gal-b- Sequence on An Intact Glycoprotein . J. Am. Chem. Soc. (1999), 121, 1411-1412.

  38. Y. Kajihara, S. Akai, T. Nakagawa, R. Sato, T. Ebata, H. Kodama, K. Sato; Enzymatic Synthesis of Kdn-oligosaccharides by Bacterial a-(2-6)-sialyltransferase. Carbohydr. Res. (1999), 315, 137-141.

  39. S. Akai, T. Nakagawa, Y. Kajihara, K. Sato; Selective Protecting Method for the Individual Hydroxyl Group of KDN. J. Carbohydr. Chem. (1999), 18, 639-654.

  40. H. Kamei , Y. Kajihara, Y. Nishi; Synthesis of a Neu2en5Ac Analog Hapten and Isolation of Monoclonal Antibody to Neu2en5Ac. Carbohydr. Res. (1999), 315, 243-250.

  41. S. Akai, Y. Nakamura, Y. Kajihara, J. Yoshimura, K. Sato; Crystralstructure of (1R, 2R, 3S,4S,6S,7R,9S)-6-azido-7-cyano-3-C-hydroxy-methyl-3,3'-di-O-isopropylidene-9-methoxy-2,4,5-tris(O-methoxymethyl)-2,3,4,5-tetrahydroxyl-8-oxabicyclo[4.3.0]nonane, Toward Tetrodotoxin. Analytical Science (1999), 15, 501-502.

  42. Y. Kajihara, H. Kodama, T. Endo, H. Hashimoto; Novel Feature of Acceptor Recognition by b-1,4-galactosyltransferase. Carbohydr. Res. (1998), 306, 361-378.

  43. T. Yamamoto, H. Nagae, Y. Kajihara, I. Terada; Mass production of Bacterial a2,6-sialyltransferase and Enzymatic Syntheses of Sialyloligosaccharides. Biosci. Biotechnol. Biochem. (1998), 62, 210-214.

  44. Y. Kajihara, T. Ebata, H. Kodama; Synthesis of Immobilized CMP-sialic acids and Their Enzymatic Transfer with Sialyltransferase. Angew. Chem. Int. Ed. (1998), 37, 3166-3169.

  45. K. Sato, K. Suzuki, M. Ueda, Y. Kajihara, H. Hori;Useful Intermediate, 3-C-Dichloromethylfuranose Derivatives for the Synthesis of Branched-chain Functionalized Sugar. Bull. Chem. Soc. Jpn. (1997), 70, 225-230.

  46. K. Hatanaka, H. Takeshige, K. Kanno, A. Maruyama, J. Oishi, Y. Kajihara, H. Hashimoto; Newpolymeric Inhibitor of Galactosyltransferase. J. Carbohydr. Chem. (1997), 16, 667-672.

  47. H. Hashimoto, T. Endo, Y. Kajihara; Synthesis of the First Tricomponent Bisubstrate Analogue that Exhibits Potent Inhibition Against GlcNAc b-1,4-galactosyltransferase. J. Org. Chem. (1997), 62, 1914-1915.

  48. Y. Kajihara, T. Yamamoto, H. Nagae, M. Nakashizuka, T. Sakakibara, I. Terada; A Novel a-2,6 Sialyltransferase: Transfer of Sialic acid to Fucosyl- and Sialyl-trisaccharides. J. Org. Chem. (1996), 61, 8632-8635.

  49. T. Endo, Y. Kajihara, H. Kodama, H. Hashimoto; Novel Aspects of Interaction between UDP-Gal and GlcNAc b-1,4-Galactosyltransferase: Transferability and Remarkable Inhibitory Activity of UDP-(Mono-O-methylated Gal), UDP-Fuc and UDP-Man. Bioorg. Med. Chem. (1996), 4, 1939-1948.

  50. T. Yamamoto, M. Nakashizuka, H. Kodama, Y. Kajihara, I.Terada; Purification and Characterization of A Marine Bacterial b-Galactoside a-2,6 sialyltransferase from Photobacterium damsela JT0160. J. Biolchem. (1996), 120, 104-110.

  51. Y. Yokoyama, K. Ogawa, T. Iwai, K. Shimazaki, Y. Kajihara, T. Goto, Y. Yokoyama, Y. Kurita; Study on the Comformation of An Isopropyl-substituted furylfulgide. Photochromic Coloring Reaction and Thermal Racemization. Bull. Chem. Soc. Jpn. (1996), 69, 1605-1612.

  52. Y. Kajihara, K. Koseki, T. Ebata, H. Kodama, H. Matsushita, H. Hashimoto ; Efficient Synthesis of CMP-NeuAc and CMP-(NeuAc a 2-8 NeuAc). J. Org. Chem. (1995), 60, 5732-5735.

  53. Y. Kajihara, T. Endo, H. Ogasawara, H. Kodama, H. Hashimoto ; Enzymic Transfer of 6-Modified D-Galactosyl Residues: Synthesis of Biantennary Penta- and Hepta-saccharides Having Two 6-Deoxy-D-galactose Residues at the Non Reducing End and Evaluation of 6-Deoxy-D-galactosyl Transfer Using Bovine b1,4- Galactosyltransferase and UDP-6-Deoxy-D-galactose to Glycoprotein. Carbohydr. Res. (1995), 269, 273-294.

  54. Y. Kajihara, K. Koseki, T. Ebata, H. Kodama, H. Matsushita, H. Hashimoto ; Synthesis of Novel CMP-NeuAc analogue : CMP-(NeuAc a 2-8 NeuAc). Carbohydr. Res. (1994), 264, C1-5.

  55. H. Kodama, Y. Kajihara, T. Endo, and H. Hashimoto ; Synthesis of UDP-6-deoxy- and -6-fluoro- galactoses and Their Enzymatic Glycosyl Transfer to Mono and Biantennary Carbohydrate Chains. Tetrahedron Lett. (1993), 34, 6419-6422.

  56. Y. Kajihara, H. Kodama, T. Wakabayashi, K. Sato, and H. Hashimoto ; Characterization of Inhibitory Activities and Binding Mode of Synthetic 6'-Modified Methyl N-acetyl-b-D-lactosaminide toward CMP-NeuAc:D-galactoside-(2-6)-a-D-sialyltransferase. Carbohydr. Res. (1993), 247, 179-193.

  57. Y. Kajihara, T. Wakabayashi, H. Hashimoto, H. Kodama, K. Sato; Synthesis of Methyl 6'-deoxy- and 6'-thio-lactosaminides and Their Inhibitory Activity Toward CMP-NeuAc:D-galactoside-(2-6)-a-D-sialyltransferase. J. Carbohydr. Chem. (1993), 12, 991-995.

  58. Y. Kajihara, H. Kodama, and H. Hashimoto ; Methyl 3-O-(2-acetamido-2-deoxy-6-thio-b-D-glucopyranosyl)- b-D-galactopyranoside : A Slow Reacting Acceptor-analogue which Inhibits Glycosylation by UDP-D-galactose-N-acetyl-D-glucosamine-(1-4)-b-D-galactosyltransferase. Carbohydr. Res. (1992), 229, C5-C9.

  59. K. Sato, T. Hoshi, and Y. Kajihara ; An Efficient Deoxysugar Synthesis using Bu4NBH4 via an SN2 Reduction. Chem. Lett. (1992), 1469-1472.

  60. K. Sato, K. Suzuki, M. Ueda, M. Katayama, and Y. Kajihara ; A Novel Reagent for the Synthesis of Branched-chain Functionalized Sugars. Dichloromethyllitium. Chem. Lett. (1991), 1469-1472.

  61. K. Sato, Y. Kajihara, Y. Nakamura, and J. Yoshimura ; Synthesis of the Functionalized Cyclohexanecarbaldehyde Derivative. A Potential Key Compound for Total Synthesis of Optically Active Tetrodotoxin. Chem. Lett. (1991), 1559-1562.