Organic Chemistry Division

Laboratory for Organic Biochemistry

Research Interests

1. Chemical synthesis ofoligosaccharides
2. Chemical synthesis of glycoproteins andglycopeptides
3. Elucidation of oligosaccharidefunctions

The oligosaccharides of protein have been thought to concern with protein conformation, dynamics, protein trafficking and glycoprotein lifetime in blood. We have examined synthesis of homogeneous glycoproteins having human complex type oligosaccharide in order to evaluate oligosaccharide functions. We have synthesized several small glycoproteins (amino acids 40-76 residues), erythropoietin analogue (amino acids 166 residues), and co-stimulate glycoprotein of T-cell (amino acids 120 residues). We have also evaluated the effect of oligosaccharide during protein folding process.