The 65th Calorimetry Conference (CALCON 2010) was held at Glen Eyrie Conference Center, Colorado Springs, USA from July 18 to 23. The conference chair was Prof. M. T. Henzl and local arrangements were perforemed by Prof. G. Kresheck at University of Colorado. There were six different Symposia, Biothermodynamics, Condensed Matter, Pharmaceutical and Biopharmaceutical Applications, Solutions and Fluid Mixtures, and Thermodynamic Databases, Modeling and Simulations during the conference. We have enjoyed a discussion of thermodynamics in various area and wonderful view in Colorado. The next CalCon20100 will be held at Turtle Bay Resort, Hawaii as a joint meeting of the North American Calorimetry Conference and the Japan Society of Calorimetry &Thermal Analysis.