In biological systems, life process is led by the unique behavior of macromolecules such as proteins and DNA. Molecular recognition by macromolecules plays an important role, for example, in substrate specificity of enzymes and antigen-antibody reactions in human life. Selective molecular recognition among macromolecules is achieved through a large number of weak interactions. We have focused our attention on the special behavior of antibodies, especially monoclonal antibodies, because they can recognize a larger and more complicated compound with high specificity than that can synthetic host molecules or enzymes.
In this laboratory, we develop novel materials through hybridization of bio-related macromolecules such as monoclonal antibodies with artificial/synthetic small molecules. We construct functionalized catalytic and energy conversion systems based on specific molecular recognition of biomacromolecules and selective assembly of bio/synthetic molecules.

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8th November, 2019
Publications updated.

Mechanical Polymeric Materials Based on Cyclodextrins as Artificial Muscles (Chapter 7)
Mechanically Responsive Materials for Soft Robotics, Koshima, H. Ed., Wiley-VCH, Weinheim, 2019, 21, 179-208.
Harada, A.; Takashima, Y.; Hashidzume, A.; Yamaguchi, H.
(ISBN:978-3-527-34620-2)

1st November, 2019
Publications updated.

X-ray crystal structures of α-cyclodextrin-5-hydroxypentanoic acid, β-cyclodextrin-5-hydroxypentanoic acid, β-cyclodextrin-ε-caprolactone, and β-cyclodextrin-ε-caprolactam inclusion complexes
J. Incl. Phenom. Macrocycl. Chem. 2019, in press
Ossaki, M.; Takashima, Y.; Kamitori, S.; Yamaguchi, H.; Harada, A.
(DOI:10.1007/s10847-019-00953-3)

20th September, 2019
Publications updated.

Atroposelective antibodies as a designed protein scaffold for artificial metalloenzymes
Sci. Rep. 2019, 9, 13551.
Adachi, T.; Harada, A.; Yamaguchi, H.
(DOI:10.1038/s41598-019-49844-0)

27th August, 2019
Publications updated.

Supramolecular Elastomers with Movable Cross-Linkers Showing High Fracture Energy Based on Stress Dispersion
Macromolecules 2019, 52, 6953-6962.
Ikura, R.; Park, J.; Osaki, M.; Yamaguchi H.; Harada, A.; Takashima, Y.
(DOI:10.1021/acs.macromol.9b01198)

17th July, 2019
Publications updated.

Self-healing and shape-memory properties of polymeric materials cross-linked by hydrogen bonding and metal?ligand interactions
Polym. Chem. 2019, 10, 4519-4523.
Kobayashi, Y.; Hirase, T.; Takashima, Y.; Harada, A.; Yamaguchi H
(DOI:10.1039/C9PY00450E)
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11th July, 2019
Publications updated.

Mechanical and self-recovery properties of supramolecular ionic liquid elastomers based on host-guest interaction and correlation with ionic liquid content
RSC Advances 2019, 9, 22295-22301.
Garry, S.; Kobayashi, Y.; Osaki, M.; Takashima, Y.; Harada, A.; Yamaguchi H
(DOI:10.1039/C9RA04623B)

6th June, 2019
Publications updated.

Development of Atroposelective Antibodies by Immunization with a Racemic Mixture of Binaphthyl Derivatives
Bull. Chem. Soc. Jpn. 2019, 92, 1462-1466.
Adachi, T.; Harada, A.; Yamaguchi, H.
(DOI:10.1246/bcsj.20190135)

5th June, 2019
Publications updated.

Preparation of cyclodextrin-based porous polymeric membrane by bulk polymerization of ethyl acrylate in the presence of cyclodextrin
Polymer 2019, 177, 208-213.
Kobayashi, Y.; Nakamitsu, Y.; Zheng, Y.; Takashima, Y.; Yamaguchi, H.; Harada, A.
(DOI:10.1016/j.polymer.2019.06.015)

6th April, 2019
Publications updated.

Cyclodextrin-Based Rotaxanes: from Rotaxanes to Polyrotaxanes and Further to Functional Materials
Hashidzume, A.; Yamaguchi, H.; Harada, A.
Eur. J. Org. Chem. 2019, in press. (Review)
(DOI:10.1002/ejoc.201900090)

1st April, 2019
Publications updated.

Preparation of Supramolecular Ionic Liquid Gels based on Host-Guest Interactions and Their Swelling and Ionic Conductive Properties
Macromolecules 2019, 52 2932-2938.
Garry, S.; Kobayashi, Y.; Yongtai, Z.; Takashima, Y.; Harada, A.; Yamaguchi H.

27th March, 2019
Publications updated.

Self-Healing Alkyl Acrylate-Based Supramolecular Elastomers Cross-Linked via Host?Guest Interactions
Nomimura, S.; Osaki, M.; Park, J.; Ikura, R.; Takashima, Y.; Yamaguchi H.; Harada, A.
Macromolecules 2019, 52 2659-2668.
(DOI:10.1021/acs.macromol.9b00471)

7th March, 2019
Publications updated.

Mechanical properties of supramolecular polymeric materials cross-linked by donor?acceptor interactions
Chem. Commun. 2019, accepted.
Itano, M.; Kobayashi, Y.; Takashima, Y.; Harada, A.; Yamaguchi H.
(DOI:10.1039/C9CC01472A)

16th January, 2019
Dr. Kobayashi has joined our lab as an assistant professor.
English language website launched