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最近の論文発表

2020

  1. "Allosteric Communication with the Retinal Chromophore upon Ion Binding in a Light-Driven Sodium Ion-Pumping Rhodopsin," Akihiro Otomo, Misao Mizuno, Keiichi Inoue, Hideki Kandori, and Yasuhisa Mizutani, Biochemistry 59, 520-529 (2020).
  2. "Role of atomic contacts in vibrational energy transfer in myoglobin," Misao Mizuno and Yasuhisa Mizutani, Biophysical Reviews 12, 511–518 (2020).
  3. "Nonbonded Atomic Contacts Drive Ultrafast Helix Motions in Myoglobin," Shinya Tahara, Misao Mizuno, and Yasuhisa Mizutani, J. Phys. Chem. B 124, 5407-5414 (2020).
  4. "Acceleration and Deceleration Factors on the Hydrolysis Reaction of 4, 6-O-Benzylidene Acetal Group," Yuta Maki, Kota Nomura, Ryo Okamoto, Masayuki Izumi, Yasuhisa Mizutani, Yasuhiro Kajihara, J. Org. Chem. in press.
  5. "Time-resolved Raman Mapping of Energy Flow in Proteins," Yasuhisa Mizutani, Satoshi Yamashita, and Misao Mizuno, in Ultrafast Electronic and Structural Dynamics, K. Ueda, Editor, 2020, Springer Nature, in press.

2019

  1. "Ultrafast Dynamics of Heliorhodopsins," Shinya Tahara, Manish Singh, Hikaru Kuramochi, Wataru Shihoya, Keiichi Inoue, Osamu Nureki, Oded Béjà, Yasuhisa Mizutani, Hideki Kandori, and Tahei Tahara, J. Phys. Chem. B 123, 2507–2512 (2019).
  2. "Distortion and a Strong Hydrogen Bond in the Retinal Chromophore Enable Sodium Ion Transport by the Sodium Ion Pump KR2," Nao Nishimura, Misao Mizuno, Hideki Kandori, and Yasuhisa Mizutani, J. Phys. Chem. B 123, 3430–3440 (2019).
  3. "Soft-chromophore featured liquid porphyrins and their utilization toward liquid-electret applications," Avijit Ghosh, Manabu Yoshida, Koji Suemori, Hiroaki Isago, Nagao Kobayashi, Yasuhisa Mizutani, Yuki Kurashige, Izuru Kawamura, Masami Nirei, Osamu Yamamuro, Tomohisa Takaya, Koichi Iwata, Akinori Saeki, Kazuhiko Nagura, Shinsuke Ishihara, and Takashi Nakanishi, Nature Commun. 10, 4210 (2019).
  4. "Effect of a bound anion on the structure and dynamics of halorhodopsin from Natronomonas pharaonis," Misao Mizuno, Yumi Shimoo, Hideki Kandori, and Yasuhisa Mizutani, Struct. Dynam. 6, 054703 (11 pages) (2019). Editor's Pickに選ばれました。
  5. "Dynamics and allostery of human hemoglobin as elucidated by time-resolved resonance Raman spectroscopy," Yasuhisa Mizutani, in Vibrational Spectroscopy in Protein Research, Y. Ozaki, I. Lednev, M. Baranska, B. Wood, Editors. 2019, Elsevier B.V., in press.
  6. 「学問への畏敬」(会誌巻頭言), 水谷泰久, 生物物理, 59, 291-291 (2019)

2018

  1. "Tertiary Dynamics of Human Adult Hemoglobin Fixed in R and T Quaternary Structures," Shanyan Chang, Misao Mizuno, Haruto Ishikawa and Yasuhisa Mizutani, Phys. Chem. Chem. Phys. 20, 3363-3372 (2018).
  2. "Structural Evolution of a Retinal Chromophore in the Photocycle of Halorhodopsin from Natronobacterium pharaonis," Misao Mizuno, Ayumi Nakajima, Hideki Kandori, and Yasuhisa Mizutani, J. Phys. Chem. A 122, 2411–2423 (2018).
  3. "Opn5L1 is a retinal receptor that behaves as a reverse and self-regenerating photoreceptor," Keita Sato, Takahiro Yamashita, Hideyo Ohuchi, Atsuko Takeuchi, Hitoshi Gotoh, Katsuhiko Ono, Misao Mizuno, Yasuhisa Mizutani, Sayuri Tomonari, Kazumi Sakai, Yasushi Imamoto, Akimori Wada and Yoshinori Shichida, Nature Commun. 9, 1255 (2018).
  4. "Vibrational Energy Transfer from Heme through Atomic Contacts in Proteins," Satoshi Yamashita, Misao Mizuno, Duy Phuoc Tran, Hisham Dokainish, Akio Kitao, and Yasuhisa Mizutani, J. Phys. Chem. B 122, 5877-5884 (2018).
  5. "Production of a Light-gated Proton Channel by Replacing the Retinal Chromophore with Its Synthetic Vinylene Derivative," Riho Takayama, Akimasa Kaneko, Takashi Okitsu, Satoshi P. Tsunoda, Kazumi Shimono, Misao Mizuno, Keiichi Kojima, Takashi Tsukamoto, Hideki Kandori, Yasuhisa Mizutani, Akimori Wada and Yuki Sudo, J. Phys. Chem. Lett. 9, 2857–2862 (2018).
  6. "High Thermal Stability of Oligomeric Assemblies of Thermophilic Rhodopsin in a Lipid Environment," Tomomi Shionoya, Misao Mizuno, Takashi Tsukamoto, Kento Ikeda, Hayato Seki, Keiichi Kojima, Mikihiro Shibata, Izuru Kawamura, Yuki Sudo, and Yasuhisa Mizutani, J. Phys. Chem. B 122, 6945-6953 (2018).
  7. "Potent Antimalarial Activity of Two Arenes Linked with Triamine Designed To Have Multiple Interactions with Heme," Yosuke Sakata, Kosuke Yabunaka, Yuko Kobayashi, Hirohisa Omiya, Naoki Umezawa, Hye-Sook Kim, Yusuke Wataya, Yoshimi Tomita, Yosuke Hisamatsu, Nobuki Kato, Hirokazu Yagi, Tadashi Satoh, Koichi Kato, Haruto Ishikawa, and Tsunehiko Higuchi, ACS Med. Chem. Lett. 9, 980–985 (2018)
  8. "Resonance Raman Investigation of the Chromophore Structure of Heliorhodopsins," Akihiro Otomo, Misao Mizuno, Manish Singh, Wataru Shihoya, Keiichi Inoue, Osamu Nureki, Oded Béjà, Hideki Kandori, Yasuhisa Mizutani, J. Phys. Chem. Lett. 9, 6431–6436 (2018).
  9. "Force Detection of High-Frequency Electron Paramagnetic Resonance Spectroscopy of Microliter Solution Sample," Tsubasa Okamoto, Hideyuki Takahashi, Eiji Ohmichi, Haruto Ishikawa, Yasuhisa Mizutani, Hitoshi Ohta, Appl. Phys. Lett. 113, 223702 (2018).

2017

  1. "Demonstration of a light-driven SO42- transporter and its spectroscopic characteristics," Akiko Niho, Susumu Yoshizawa, Takashi Tsukamoto, Marie Kurihara, Shinya Tahara, Yu Nakajima, Misao Mizuno, Hikaru Kuramochi, Tahei Tahara, Yasuhisa Mizutani and Yuki Sudo, J. Am. Chem. Soc. 139, 4376–4389 (2017).
  2. "Time-resolved Resonance Raman Spectroscopy and Application to Studies on Ultrafast Protein Dynamics," Yasuhisa Mizutani, Bull. Chem. Soc. Jpn. 90, 1344 – 1371 (2017).

2016

  1. "Effect of the N-terminal residues on the quaternary dynamics of human adult hemoglobin," Shanyan Chang, Misao Mizuno, Haruto Ishikawa and Yasuhisa Mizutani, Chem. Phys. 469–470, 31–37 (2016).
  2. "Chromophore Structure of Photochromic Fluorescent Protein Dronpa: Acid-base Equilibrium of Two cis Configurations," Asuka Higashino, Misao Mizuno, and Yasuhisa Mizutani, J. Phys. Chem. B 120, 3353–3359 (2016).
  3. "Importance of Atomic Contacts in Vibrational Energy Flow in Proteins," Masato Kondoh, Misao Mizuno, and Yasuhisa Mizutani, J. Phys. Chem. Lett. 7, 1950–1954 (2016).
  4. "Regulatory Implications of Structural Changes in Tyr201 of the Oxygen Sensor Protein FixL," Takeo Yamawaki, Haruto Ishikawa, Misao Mizuno, Hiro Nakamura, Yoshitsugu Shiro, and Yasuhisa Mizutani, Biochemistry 55, 4027–4035 (2016).
  5. "A Study of the Dynamics of the Heme Pocket and C-helix in CooA Upon CO Dissociation Using Time-resolved Visible and UV Resonance Raman Spectroscopy," Akihiro Otomo, Haruto Ishikawa, Misao Mizuno, Tetsunari Kimura, Minoru Kubo, Yoshitsugu Shiro, Shigetoshi Aono, and Yasuhisa Mizutani, J. Phys. Chem. B 120, 7836–7843 (2016).

2015

  1. "Carbon monoxide binding properties of domain-swapped dimeric myoglobin," Satoshi Nagao, Haruto Ishikawa, Takuya Yamada, Yasuhisa Mizutani, and Shun Hirota, J. Biol. Inorg. Chem. 20, 523–530 (2015).
  2. "Protein response to chromophore isomerization in microbial rhodopsins revealed by picosecond time-resolved ultraviolet resonance Raman spectroscopy: a review," Misao Mizuno and Yasuhisa Mizutani, In Recent progress in colloid and surface chemistry with biological applications, American Chemical Society: 2015; Vol. 1215, pp 329-353.
  3. "Vibrational Energy Flow in Hemeproteins," Yasuhisa Mizutani, Naoki Fujii, Mitsuhiro Miyamoto, Misao Mizuno, and Haruto Ishikawa, in Ultrafast Phenomena XIX, K. Yamanouchi, et al., Editors. 2015, Springer International Publishing, p. 532-534.
  4. 「時間分解共鳴ラマン分光法によるヘモグロビンのPerutz機構のリアルタイム観測」, 水谷泰久, 生物物理, 55, 95-97 (2015).
  5. 「レーザー技術の発展とタンパク質超高速ダイナミクス研究」, 水野操, 水谷泰久, 生物物理, 55, 322-328 (2015).

2014

  1. "The Early Steps in the Photocycle of a Photosensor Protein Sensory Rhodopsin I from Salinibacter ruber", Yuki Sudo, Misao Mizuno, Zhengrong Wei, Satoshi Takeuchi, Tahei Tahara, and Yasuhisa Mizutani, J. Phys. Chem. B 118, 1510–1518 (2014).
  2. "Observing Vibrational Energy Flow in a Protein with the Spatial Resolution of a Single Amino Acid Residue", Naoki Fujii, Misao Mizuno, Haruto Ishikawa, and Yasuhisa Mizutani, J. Phys. Chem. Lett. 5, 3269–3273 (2014).
  3. "Critical Histidine Residues Regulate Hemozoin Formation Activity of the Heme Detoxification Protein in Plasmodium falciparum", Keisuke Nakatani, Haruto Ishikawa, Shigetoshi Aono, Yasuhisa Mizutani, Sci. Rep. 4, 6137 (2014).

2013

  1. "Primary Structural Response in Tryptophan Residues of Anabaena Sensory Rhodopsin to Photochromic Reactions of the Retinal Chromophore", Seisuke Inada, Misao Mizuno, Yoshitaka Kato, Akira Kawanabe, Hideki Kandori, Zhengrong Wei, Satoshi Takeuchi, Tahei Tahara, and Yasuhisa Mizutani, Chem. Phys. 419, 65-73 (2013).
  2. "Large Spectral Change Due to Amide Modes of a β-Sheet upon the Formation of an Early Photointermediate of Middle Rhodopsin", Yuji Furutani, Takashi Okitsu, Louisa Reissig, Misao Mizuno, Michio Homma, Akimori Wada, Yasuhisa Mizutani, and Yuki Sudo, J. Phys. Chem. B 117, 3449–3458 (2013).
  3. "Heme-Binding Properties of Heme Detoxification Protein from Plasmodium falciparum", Keisuke Nakatani, Haruto Ishikawa, Shigetoshi Aono, and Yasuhisa Mizutani, Biochem. Biophys. Res. Comm. 439, 477–480 (2013).
  4. "Intersubunit communication via changes in hemoglobin quaternary structures revealed by time-resolved resonance Raman spectroscopy: Direct observation of the Perutz mechanism", Kenta Yamada, Haruto Ishikawa, Misao Mizuno, Naoya Shibayama, and Yasuhisa Mizutani, J. Phys. Chem. B 117, 12461–12468 (2013).
  5. "Ultraviolet Resonance Raman Observations of the Structural Dynamics of Rhizobial Oxygen Sensor FixL on Ligand Recognition", Shinji Yano, Haruto Ishikawa, Misao Mizuno, Hiro Nakamura, Yoshitsugu Shiro, and Yasuhisa Mizutani, J. Phys. Chem. B 117, 15786–15791 (2013).
  6. 「タンパク質分子における“熱”エネルギーの散逸過程」, 水野 操, 水谷 泰久, 熱測定, 40, 139-145 (2013).

2012

  1. "Differences between Protein Dynamics of Hemoglobin upon Dissociation of Oxygen and Carbon Monoxide", Yuka Murakawa, Masako Nagai and Yasuhisa Mizutani, J. Am. Chem. Soc. 134, 1434-1437 (2012).
  2. "Ultrafast Protein Dynamics of Hemoglobin as Studied by Picosecond Time-resolved Resonance Raman Spectroscopy", Yasuhisa Mizutani and Masako Nagai,Chem. Phys. 396, 45-52 (2012).
  3. "Protein Dynamics of Isolated Chains of Recombinant Human Hemoglobin Elucidated by Time-resolved Resonance Raman Spectroscopy", Kenta Yamada, Haruto Ishikawa, and Yasuhisa Mizutani, J. Phys. Chem. B 116, 1992–1998 (2012).
  4. "Structural Dynamics of Proximal Heme Pocket in HemAT-Bs Associated with Oxygen Dissociation", Yuu Yoshida, Haruto Ishikawa, Shigetoshi Aono, and Yasuhisa Mizutani, Biochim. Biophys. Acta - Proteins and Proteomics 1824, 866–872 (2012).
  5. "Structural Basis for Oxygen Sensing and Signal Transduction of the Heme-based Sensor Protein Aer2 from Pseudomonas aeruginosa", Hitomi Sawai, Hiroshi Sugimoto, Yoshitsugu Shiro, Haruto Ishikawa, Yasuhisa Mizutani and Shigetoshi Aono, Chem. Comm. 48, 6523–6525 (2012).

2011

  1. "Protein dynamics of heme-heme oxygenase-1 complex following carbon monoxide dissociation", Masato Yamaoka, Masakazu Sugishima, Masato Noguchi, Keiichi Fukuyama and Yasuhisa Mizutani, J. Raman Spectrosc. 42, 910–916 (2011).
  2. "Direct observation of the structural change of Tyr174 in the primary reaction of sensory rhodopsin II", Misao Mizuno*, Yuki Sudo*, Michio Homma and Yasuhisa Mizutani, Biochemistry 50, 3170–3180 (2011).
    *These authors equally contributed to this work
  3. "Changes in the Hydrogen-Bond Network around the Chromophore of Photoactive Yellow Protein in the Ground and Excited States", Misao Mizuno, Hironari Kamikubo, Mikio Kataoka and Yasuhisa Mizutani, J. Phys. Chem. B 115, 9306–9310 (2011).
  4. "Direct observation of vibrational energy flow in cytochrome c", Naoki Fujii, Misao Mizuno, and Yasuhisa Mizutani, J. Phys. Chem. B 115, 13057–13064 (2011).
  5. "Protein Conformational Changes in the Oxidative-Stress Sensor, SoxR, upon Redox Change of the [2Fe-2S] Cluster Probed with Ultraviolet Resonance Raman Spectroscopy", Kazuo Kobayashi, Misao Mizuno, and Yasuhisa Mizutani, Biochemistry 50, 9468–9474 (2011).
  6. 「ピコ秒時間分解紫外共鳴ラマン分光法でみたタンパク質分子の光反応応答」, 水谷泰久, 水野操, 生物物理, 51, 10-13 (2011).
  7. 「タンパク質ダイナミクスの実時間観測」, 水谷泰久, パリティ, 26, 52-56 (2011).

2009

  1. 「タンパク質ダイナミクス観測のための時間分解共鳴ラマン分光計開発」, 水野操, 水谷泰久, レーザー研究, 37, 748-753 (2009).
  2. "Picosecond Time-Resolved Ultraviolet Resonance Raman Spectroscopy of Bacteriorhodopsin: Primary Protein Response to the Photoisomerization of Retinal", Misao Mizuno, Mikihiro Shibata, Junya Yamada, Hideki Kandori, and Yasuhisa Mizutani, J. Phys. Chem. B 113, 12121–12128 (2009).

2008

  1. "Photoinduced Dynamics of TiO2 Doped with Cr and Sb", Toshitatsu Ikeda, Tomonori Nomoto, Kazuo Eda, Yasuhisa Mizutani, Hideki Kato, Akihiko Kudo, and Hiroshi Onishi, J. Phys. Chem. C 112, 1167 -1173 (2008).
  2. "Ruthenium-Catalyzed Selective and Efficient Oxygenation of Hydrocarbons with Water as an Oxygen Source", Takahiko Kojima, Yuichirou Hirai, Yasuhisa Mizutani, Yoshihito Shiota, Kazunari Yoshizawa, Shunichi Fukuzumi, Angew. Chem. Int. Ed. 47, 5772-5776 (2008).
  3. 「共鳴効果を利用する生体分子の部位特異的ダイナミクス観測」, 水野操, 水谷泰久, 分光研究,57, 179-194 (2008).
  4. "Photoinduced Electron Transfer in Glucose Oxidase: a Picosecond Time-resolved Ultraviolet Resonance Raman Study", Akiko Fujiwara and Yasuhisa Mizutani, J. Raman Spectrosc. 39, 1600-1605 (2008).

2007

  1. "Resonance Raman Observation of the Structural Dynamics of FixL on Ligand Recognition and Signaling", Yusuke Hiruma, Akihiro Kikuchi, Atsunari Tanaka, Yoshitsugu Shiro, and Yasuhisa Mizutani, Biochemistry 46, 6086-6096 (2007).
  2. "The Formation of Hydrogen Bond in the Proximal Heme Pocket of HemAT-Bs upon Ligand Binding", Hideaki Yoshimura, Shiro Yoshioka, Yasuhisa Mizutani, and Shigetoshi Aono, Biochem. Biophys. Res. Commun. 357, 1053-1057 (2007).
  3. "Picosecond Protein Response to the Chromophore Isomerization of Photoactive Yellow Protein: Selective Observation of Tyrosine and Tryptophan Residues by Time-Resolved Ultraviolet Resonance Raman Spectroscopy", Misao Mizuno, Norio Hamada, Fumio Tokunaga, and Yasuhisa Mizutani, J. Phys. Chem. B 111, 6293-6296 (2007).
  4. "Primary protein response after ligand photodissociation in carbonmonoxy myoglobin", Akira Sato, Ying Gao, Teizo Kitagawa, and Yasuhisa Mizutani, Proc. Natl. Acad. Sci. USA 104, 9627-9632 (2007).
  5. 「時間分解共鳴ラマン分光法で観るヘムタンパク質の構造ダイナミクスと機能発現機構」, 水谷泰久, 生物物理, 47, 288-294 (2007)
  6. 「時間分解振動分光法によるタンパク質のダイナミクス解析」, 水谷泰久, 光学, 36, 516-523 (2007).

2006

  1. "Time-resolved Raman Evidence for Energy "Funneling" through Propionate Side Chains in Heme "Cooling" upon Photolysis of Carbonmonoxy Myoglobin", Ying Gao, Mai Koyama, Samir F. El-Mashtoly, Takashi Hayashi, Katsuyoshi Harada, Yasuhisa Mizutani and Teizo Kitagawa, Chem. Phys. Lett. 429, 239-243 (2006).
  2. "Role of heme propionates of myoglobin in vibrational energy relaxation", Mai Koyama, Saburo Neya, and Yasuhisa Mizutani, Chem. Phys. Lett. 430, 404-408 (2006).
  3. "Evidence for Displacements of C-Helix by CO Ligation and DNA Binding to CooA Revealed by UV Resonance Raman Spectroscopy", Minoru Kubo, Sayaka Inagaki, Takeshi Uchida, Yasuhisa Mizutani, Shigetoshi Aono, and Teizo Kitagawa, J. Biol. Chem. 281, 11271-11278 (2006).

2005

  1. "Picosecond Structural Dynamics of Myoglobin following Photodissociation of Carbon Monoxide As Revealed by Ultraviolet Time-Resolved Resonance Raman Spectroscopy", Akira Sato and Yasuhisa Mizutani, Biochemistry 44, 14709-14714 (2005).
  2. "Structural Characterization of the Proximal and Distal Histidine Environment of Cytoglobin and Neuroglobin", Hitomi Sawai, Masatomo Makino, Yasuhisa Mizutani, Takehiro Ohta, Hiroshi Sugimoto, Tadayuki Uno, Norifumi Kawada, Katsutoshi Yoshizato, Teizo Kitagawa, and Yoshitsugu Shiro, Biochemistry 44, 13257-13265 (2005).
  3. "Quaternary Structures of Intermediately Ligated Human Hemoglobin A and Influences from Strong Allosteric Effectors: Resonance Raman Investigation", Shigenori Nagatomo, Masako Nagai, Yasuhisa Mizutani, Takashi Yonetani and Teizo Kitagawa, Biophys. J. 89, 1203-1213 (2005).
  4. "Isotope Dilution Effects on the Hydroxyl Stretch Bands of Alcohols", Takanori Uemura, Shinji Saito, Yasuhisa Mizutani and Keisuke Tominaga, Mol. Phys.103, 37-44 (2005). 

2004年以前の水谷の論文に関してはこちらをご覧ください。